CLINICAL RELEVANCE AND MANAGEMENT OF THE MAJOR ELECTROLYTE ABNORMALITIES IN CONGESTIVE-HEART-FAILURE - HYPONATREMIA, HYPOKALEMIA, AND HYPOMAGNESEMIA
CLINICAL RELEVANCE AND MANAGEMENT OF THE MAJOR ELECTROLYTE ABNORMALITIES IN CONGESTIVE-HEART-FAILURE - HYPONATREMIA, HYPOKALEMIA, AND HYPOMAGNESEMIA
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DOI：
10.1016/0002-8703(94)90633-5
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发表时间：
1994-09-01
影响因子：
4.8
通讯作者：
METRA, M
中科院分区：
文献类型：
--
作者：
LEIER, CV;CAS, LD;METRA, M
电解质紊乱是慢性心力衰竭的常见并发症。CHF为这些扰动的发展提供了一个完美的环境；肾功能障碍、神经激素物质升高、肾素-血管紧张素-醛固酮轴的激活和利尿剂治疗是主要的促成因素。低钠血症与不良的临床病程密切相关。低钾血症与室性心律失常增加有关。晚期CHF低镁血症可伴有心律失常和难治性低钾血症。CHF也为这些紊乱的威胁性临床后果（临床恶化、心律失常或死亡）提供了理想的环境（患病、缺血和致心律失常的心肌；升高的儿茶酚胺和致心律失常药物）。这些结果强调了认识、认识和处理这些电解质异常的重要性。
Electrolyte disturbances are a common complication of CHF. CHF provides a perfect milieu for the development of these disturbances; renal dysfunction, elevation of neurohormonal substances, activation of the renin-angiotensin-aldosterone axis, and diuretic therapy represent the major contributory factors. Hyponatremia is closely aligned with an unfavorable clinical course. Hypokalemia is associated with increased ventricular dysrhythmias. Hypomagnesemia noted in advanced CHF can be accompanied by arrhythmias and refractory hypokalemia. CHF also offers the ideal milieu (diseased, ischemic, and arrhythmogenic myocardium; elevated catecholamines; and arrhythmogenic drugs) for the threatening clinical consequences (clinical deterioration, dysrhythmias, or death) of these disturbances. These consequences underscore the importance of the recognition, appreciation, and management of these electrolyte abnormalities.