Radiological study of gastrointestinal motor activity after acute cisplatin in the rat.: Temporal relationship with pica
Radiological study of gastrointestinal motor activity after acute cisplatin in the rat.: Temporal relationship with pica
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DOI：
10.1016/j.autneu.2008.05.004
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发表时间：
2008-08-18
影响因子：
2.7
通讯作者：
Abalo, Raquel
中科院分区：
文献类型：
--
作者：
Antonio Cabezos, Pablo;Vera, Gema;Abalo, Raquel
恶心和呕吐是化疗最严重的剂量限制副作用之一。大鼠的催产活性只能通过间接标记物来评估，如Pica(高岭土摄入量)或胃排空延迟。本工作的目的是用放射学方法研究急性顺铂对大鼠胃肠运动的影响，并将其与异食癖的发生发展进行比较。大鼠在第0天给予顺铂(0-6 mg kg(-1))。在Pica研究中，每天(从第三天到第三天)测量个人食物摄入量和高岭土摄入量。在放射学研究中，清醒大鼠在注射顺铂后0、24或48h分别给予中等剂量造影剂灌胃，造影剂后0~24h拍摄系列X线片。顺铂可剂量依赖性地诱导胃停滞和胃扩张，并与急性和延迟性胃异食癖的诱导存在严格的时间关系。放射学方法是一种非侵入性的、保护动物福利的方法，有助于研究催吐药物在不同胃肠道区域的作用，并可能加速寻找新的止吐药物。(C)2008爱思唯尔B.V.保留所有权利。
Nausea and vomiting are amongst the most severe dose-limiting side effects of chemotherapy. Emetogenic activity in rats can only be evaluated by indirect markers, such as pica (kaolin intake), or delay in gastric emptying. The aim of this work was to study, by radiological methods, the alterations in gastrointestinal motility induced by acute cisplatin in the rat, and to compare them with the development of pica. Rats received cisplatin (0-6 mg kg(-1)) at day 0. In the pica study, individual food ingestion and kaolin intake were measured each day (from day -3 to day 3). In the radiological study, conscious rats received an intragastric dose of medium contrast 0, 24 or 48 h after cisplatin injection, and serial X-rays were taken 0-24 It after contrast. Cisplatin dose-dependently induced both gastric stasis and stomach distension, showing a strict temporal relationship with the induction of both acute and delayed pica. Radiological methods, which are non-invasive and preserve animals' welfare, are useful to study the effect of emetogenic drugs in the different gastrointestinal regions and might speed up the search for new anti-emetics. (c) 2008 Elsevier B.V. All rights reserved.