[18FDG-PET in intracranial meningiomas versus grading, proliferation index, cellular density and cytogenetic analysis].
[18FDG-PET in intracranial meningiomas versus grading, proliferation index, cellular density and cytogenetic analysis].
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发表时间：
1994-08
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通讯作者：
U. Cremerius;E. Striepecke;W. Henn;J. Weis;M. Mull;B. Lippitz;J. Gilsbach;J. Schröder;K. Zang;A. Böcking
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作者：
U. Cremerius;E. Striepecke;W. Henn;J. Weis;M. Mull;B. Lippitz;J. Gilsbach;J. Schröder;K. Zang;A. Böcking
本文对60例62个脑膜瘤患者术前进行了18FDG PET显像，以评价肿瘤的18FDG摄取与肿瘤生物学侵袭性的关系。组织学分级、细胞密度、Ki-67增殖指数和染色体畸变的证据用于评估肿瘤的侵袭性。与1级脑膜瘤相比，2级和3级脑膜瘤的18 FDG摄取显著升高，与低细胞性脑膜瘤相比，高细胞性脑膜瘤的18 FDG摄取显著升高，Ki-67增殖指数升高的脑膜瘤的18 FDG摄取显著升高（高于2%）。最明显的染色体畸变的两个脑膜瘤显示所有细胞遗传学研究的脑膜瘤的最高18FDG摄取。我们的结论是，18FDG-PET是有用的估计颅内脑膜瘤的生物侵袭性。
62 intracranial meningiomas in 60 patients were studied with 18FDG-PET prior to neurosurgery in order to evaluate the relationship between 18FDG uptake and biological aggressiveness of the tumors. Histopathological grading, cellular density, Ki-67 proliferation index and evidence of chromosomal aberrations were used to assess tumor aggressiveness. Significantly elevated 18FDG uptake was found in grade 2- and 3- compared to grade 1-meningiomas, in tumors of high cellularity compared with those of low cellularity, and in meningiomas with an elevated Ki-67 proliferation index (above 2%). The two meningiomas with the most pronounced chromosomal aberrations revealed the highest 18FDG uptake of all cytogenetically studied meningiomas. We conclude that 18FDG-PET is useful for estimating the biological aggressiveness of intracranial meningiomas.