The IL-28 genotype: how it will affect the care of patients with hepatitis C virus infection.
The IL-28 genotype: how it will affect the care of patients with hepatitis C virus infection.
复制标题
DOI：
10.1007/s11894-010-0161-9
复制
发表时间：
2011-02-01
影响因子：
--
通讯作者：
Pearlman, Brian L
中科院分区：
文献类型：
--
作者：
Pearlman, Brian L
宿主遗传学不仅在清除急性丙型肝炎感染的能力中，而且在对干扰素（IFN）为基础的治疗实现持续病毒学应答（SVR）的能力中发挥重要作用的假设已被最近发现的19号染色体上的两个单核苷酸多态性所证实。次要等位基因rs 8099917和邻近多态性rs 12979860（编码内源性抗病毒细胞因子IFN-λ的白细胞介素（IL）-28 B基因上游3 kb）的变体与SVR和自然病毒清除相关。这些等位基因在全世界不同种族群体中的不同频率可以很好地解释它们之间SVR的不同比率。这些多态性之一的测试现在是商业化的，可以作为一个强大的预测患者的机会实现SVR。也许更重要的是，该测试可以帮助临床医生个人定制的持续时间，甚至是最适合个别患者的治疗类型，新的或慢性感染丙型肝炎病毒。
The hypothesis that host genetics play an essential role in the ability not only to clear acute hepatitis C infection but also to achieve sustained virologic response (SVR) to interferon (IFN)-based therapy has been proved with the recent discovery of two single-nucleotide polymorphisms on chromosome 19. Variants in the minor allele rs8099917 and the proximate polymorphism rs12979860, 3kb upstream of the interleukin (IL)-28B gene, which encodes the endogenous antiviral cytokine IFN-lambda, are associated with SVR and with natural viral clearance. The disparate frequencies of these alleles in ethnic groups worldwide may well explain differing rates of SVR among them. The test for one of these polymorphisms is now commercially available and can serve as a powerful predictor of a patient's chance of achieving SVR. Perhaps more importantly, the test can help the clinician personally tailor the duration and even the type of therapy that is most appropriate for an individual patient, newly or chronically infected with the hepatitis C virus.