Effect of cervical cytologic status on the association between human papillomavirus type 16 DNA load and the risk of cervical intraepithelial neoplasia grade 3.
Effect of cervical cytologic status on the association between human papillomavirus type 16 DNA load and the risk of cervical intraepithelial neoplasia grade 3.
复制标题
宫颈细胞学状态对人乳头瘤病毒 16 型 DNA 载量与宫颈上皮内瘤变 3 级风险之间关系的影响。
DOI：
10.1086/589715
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Koutsky,LauraA
中科院分区：
文献类型：
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作者：
Xi,LongFu;Kiviat,NancyB;Galloway,DeniseA;Zhou,Xiao-Hua;Ho,Jesse;Koutsky,LauraA
Background Although correlations of cervical cytology to human papillomavirus (HPV) load and histopathology are recognized, it is largely undetermined whether viral load-related risks of cervical intraepithelial neoplasia III (CIN3) differ by cytology. Methods Study subjects were 821 women enrolled in the ASCUS-LSIL Triage Study who were positive for HPV16 at entry. Women were followed semi-annually over 2 years. Baseline HPV16 load was measured by real-time PCR; expressed as log10 [HPV16 copies per-nanogram of cellular DNA]. Results CIN3 was confirmed in 34.8% of 821 women during 2-year follow-up. The adjusted odds ratio (OR) associating 2-year cumulative risk of CIN3 with per log10–unit increase in HPV16 load was 1.46 (95%CI, 1.29-1.64). The ORs varied from 1.66 (95%CI, 1.16-2.37) for women with normal cytology at enrollment to 0.86 (95%CI, 0.61-1.20) for those with HSIL. Among women with normal cytology at enrollment, the area under the receiver operating characteristic curve for detecting CIN3 by viral load was 0.70 (95%CI, 0.61-0.78). Conclusion HPV16 DNA load was associated with CIN3 risk but the associations varied with cytology detected at the time when the viral load was measured. Clinical utility of testing for HPV16 load for CIN3 detection was minimal even in women with normal cytology.
