Post-translational modifications of protein in response to ionizing radiation
Post-translational modifications of protein in response to ionizing radiation
复制标题
响应电离辐射的蛋白质翻译后修饰
DOI：
10.1002/cbf.3467
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Shumei Ma
中科院分区：
文献类型：
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作者：
Xiaodong Liu;Rui Liu;Yongheng Bai;Heya Jiang;Xinxin Fu;Shumei Ma
基于遗传学的中心法则，蛋白质是遗传功能的体现者和执行者，蛋白质的翻译后修饰（posttranslational modifications，PTMs）尤为重要，几乎涉及细胞生物学和发病机制的各个方面。研究表明，电离辐射（IR）对基因表达的影响更为深远，并对多种细胞过程途径、许多蛋白质进行了修饰和激活。我们对蛋白质对电离辐射的反应的理解正在不断增加。在已知诱导辐射抗性的各种生物过程中，近年来，PTM引起了显著的关注。本文综述了电离辐射对PTMs的影响及其途径分析的最新研究进展。这些数据为IR的生物学效应提供了见解，并有助于开发基于IR的新策略。
Based on central dogma of genetics, protein is the embodiment and executor of.genetic function, post-translational modifications (PTMs) of protein are particularly.important and involved in almost all aspects of cell biology and pathogenesis. Studies.have shown that ionizing radiation (IR) alters gene expression much more profoundly.and a broad variety of cell-process pathways, lots of proteins are modified and activated. Our understanding of the protein in response to ionizing radiation is steadily.increasing. Among the various biological processes known to induce radioresistance,.PTMs have attracted marked attention in recent years. The present review summarizes the latest knowledge about how PTMs response to ionizing radiation and pathway analysis were conducted. The data provided insights into biological effects of IR and contributing to the development of novel IR-based strategies.