Endocrine and inflammatory markers as predictors of frailty
Endocrine and inflammatory markers as predictors of frailty
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DOI：
10.1111/j.1365-2265.2005.02355.x
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发表时间：
2005-10-01
影响因子：
3.2
通讯作者：
Lips, P
中科院分区：
文献类型：
--
作者：
Puts, MTE;Visser, M;Lips, P
目的探讨血清25-羟基维生素D [25(OH)D]、白细胞介素-6 （IL-6）、c -反应蛋白（CRP）和IGF-1浓度与常发性和非常发性虚弱的关系。阿姆斯特丹纵向老龄化研究（LASA）是一项前瞻性队列研究，测量周期为3年。一般基于人群的样本。调查对象为年龄在65岁及以上的男女，分别于T-1 （1995/1996, N = 1720）和T-2 （1998/1999, N = 1509）进行调查。T-1时采集血样（N = 1271）。在T-1和3年虚弱发生率时虚弱的存在。脆弱的定义是在9个脆弱指标中存在3个。结果12岁时，242例（19.0%）被调查者身体虚弱。那些T-1水平较弱的人有较高的CRP和较低的25(OH)D水平。调整潜在混杂因素后，血清25(OH)D仍与虚弱相关，25(OH)D < 25 nmol/l的奇比（OR）为2.60[95%置信区间（95% CI） 1.60-4.21], 25(OH)D 25-50 nmol/l与高水平25(OH)D的奇比（OR）为1.72 （95% CI 1.19-2.47）。在T-1时不虚弱的人中，125人（14.1%）在T-2时变得虚弱。调整后，中度升高的CRP水平（3-10 μ g/ml） （OR 1.69, 95% CI 1.09-2.63）和低25(OH)D （OR 2.04, 95% CI 1.01-4.13）与事件虚弱相关。IL-6和IGF-1没有一致的相关性。结论低25(OH)D水平与常见于和偶发性虚弱密切相关；中度升高的CRP水平与事件虚弱相关。
Objective To examine the association of serum concentrations of 25-hydroxyvitamin D [25(OH)D], interleukin-6 (IL-6), C-reactive protein (CRP) and IGF-1 with prevalent and incident frailty.Design The Longitudinal Aging Study Amsterdam (LASA), a prospective cohort study with 3-yearly measurement cycles.Setting General population-based sample.Participants The respondents were men and women aged 65 and over, who participated at T-1 (1995/1996, N = 1720) and T-2 (1998/1999, N = 1509). Blood samples were obtained at T-1 (N = 1271).Measurements The presence of frailty at T-1 and 3-year incidence of frailty. Frailty is defined as the presence of three out of nine frailty indicators.Results At T-1, 242 (19.0%) of all respondents were frail. Those who were frail at T-1 had higher CRP and lower 25(OH)D levels. Serum 25(OH)D remained associated with frailty after adjustment for potential confounders with an odd ratios (OR) of 2.60 [95% confidence interval (95% CI) 1.60-4.21] for 25(OH)D < 25 nmol/l and 1.72 (95% CI 1.19-2.47) for 25(OH)D 25-50 nmol/l vs. high levels of 25(OH)D. Of the nonfrail at T-1, 125 respondents (14.1%) became frail at T-2. After adjustment, moderately elevated CRP levels (3-10 mu g/ml) (OR 1.69, 95% CI 1.09-2.63) and low 25(OH)D (OR 2.04, 95% CI 1.01-4.13) were associated with incident frailty. No consistent associations were observed for IL-6 and IGF-1.Conclusion Low 25(OH)D levels were strongly associated with prevalent and incident frailty; moderately elevated levels of CRP were associated with incident frailty.