Genetic variation for resistance to the specific fly pathogen Entomophthora muscae.
Genetic variation for resistance to the specific fly pathogen Entomophthora muscae.
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针对特定苍蝇病原体 Entomophthora muscae 的遗传变异。
DOI：
10.1038/s41598-020-71262-w
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发表时间：
2020
影响因子：
4.6
通讯作者：
StLeger,RaymondJ
中科院分区：
文献类型：
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作者：
Wang,JonathanB;Elya,Carolyn;StLeger,RaymondJ
我们发现，在果蝇遗传参考小组（DGRP）的20个品系中，对蝇特异性病原体蝇虫霉“伯克利”（虫霉门）的抗性存在显著差异。对E的抗性。家蝇对广泛寄主范围的子囊菌昆虫病原体金龟子绿僵菌（Ma549）的抗性与其对该菌的抗性呈正相关（r = 0.55），表明其为多面手（非特异性）防御。对Ma549抗性高于平均水平的株系，多数对E表现交互抗性。苍蝇。然而，迅速屈服于Ma549的品系表现出对E的全部抗性。苍蝇。这表明果蝇种群在E.家蝇特异性抗性机制以及对Ma549和E.苍蝇。我们寻找的权衡，可以解释线间的变化，但增加（减少）抗病性E。蝇并不总是与抗氧化应激、饥饿应激和睡眠指数的增加（减少）相关。这些病原体是选择宿主的动力因子，这反映在来自野生种群的品系的抗性遗传变异中。
We found substantial variation in resistance to the fly-specific pathogenEntomophthora muscae'Berkeley' (Entomophthoromycota), in 20 lines from theDrosophila melanogasterGenetic Reference Panel (DGRP). Resistance toE. muscaeis positively (r = 0.55) correlated with resistance to the broad host range ascomycete entomopathogenMetarhizium anisopliae(Ma549), indicative of generalist (non-specific) defenses. Most of the lines showing above average resistance to Ma549 showed cross-resistance toE. muscae. However, lines that succumbed quickly to Ma549 exhibited the full range of resistance toE. muscae. This suggests fly populations differ inE. muscae-specific resistance mechanisms as well as generic defences effective against both Ma549 andE. muscae. We looked for trade-offs that could account for inter-line variation, but increases (decreases) in disease resistance toE. muscaeare not consistently associated with increases (decreases) of resistance to oxidative stress, starvation stress and sleep indices. That these pathogens are dynamic agents of selection on hosts is reflected in this genetic variation for resistance in lines derived from wild populations.