Human ocular dominance columns as revealed by high-field functional magnetic resonance imaging
Human ocular dominance columns as revealed by high-field functional magnetic resonance imaging
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DOI：
10.1016/s0896-6273(01)00477-9
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发表时间：
2001-10-25
期刊：
影响因子：
16.2
通讯作者：
Tanaka, K
中科院分区：
文献类型：
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作者：
Cheng, K;Waggoner, RA;Tanaka, K
我们使用高场（4 T）功能性磁共振成像（fMRI），采用分段回波平面成像技术和0.47 x 0.47 mm的面内分辨率，绘制了正常人类受试者的眼优势柱（ODC）（2）。左眼或右眼刺激的不同反应可以在V1的解剖学上明确定义的部分中可靠地解决。ODC条纹的方向和宽度（约1mm）与细胞色素氧化酶染色的死后脑中所显示的一致。此外，我们发现，映射的ODC模式可以在很大程度上再现在同一实验会话或不同的会话中进行的不同实验。我们的研究结果表明，高场功能磁共振成像可以用于研究人脑功能的柱状空间分辨率。
We mapped ocular dominance columns (ODCs) in normal human subjects using high-field (4 T) functional magnetic resonance imaging (fMRI) with a segmented echo planar imaging technique and an in-plane resolution of 0.47 x 0.47 mm(2). The differential responses to left or right eye stimulation could be reliably resolved in anatomically well-defined sections of V1. The orientation and width (similar to1 mm) of mapped ODC stripes conformed to those previously revealed in postmortem brains stained with cytochrome oxidase. In addition, we showed that mapped ODC patterns could be largely reproduced in different experiments conducted within the same experimental session or over different sessions. Our results demonstrate that high-field fMRI can be used for studying the functions of human brains at columnar spatial resolution.