Retrospective cohort study of 163 pediatric glaucoma patients
Retrospective cohort study of 163 pediatric glaucoma patients
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DOI：
10.3129/i09-065
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发表时间：
2009-06-01
影响因子：
4.2
通讯作者：
Prot-Labarthe, Sonia
中科院分区：
文献类型：
--
作者：
Bussieres, Jean-Francois;Therrien, Roxane;Prot-Labarthe, Sonia
Objective: The aim of our study was to describe a cohort of pediatric glaucoma patients in Quebec.Design: This study was a retrospective medical record review.Participants: The study included patients younger than 18 years who were diagnosed with glaucoma between 1980 and 2000 and monitored at the Ophthalmology Clinic of the Sainte-Justine University Hospital Centre (Centre Hospitalier Universitaire Sainte-Justine) and had ocular hypertension or glaucoma in at least I eye.Methods: The data gathered concerned patients' information, the surgical procedures performed post diagnosis associated with the glaucoma diagnosis, and the drugs prescribed.Results: The study included 163 patients (254 eyes), a total of 374 surgical procedures, and the use of 2885 anti-glaucoma drug therapies. For the 4 most frequent pathologies, patients were monitored for 8.4 (SD 4.2) years for aphakic glaucoma/pseudophakic glaucoma, 10.0 (SD 5.5) years for congenital glaucoma, 9.0 (SD 5.2) years for Axenfeld-Rieger syndrome, and 7.5 (SD 3.4) years for uveitic glaucoma. In total, 113 patients had at least I surgical procedure (69.3%). Before 1985, only timolol, pilocarpine, epinephrine, acetazolamide, and dipivefrin were used. Other beta blockers then appeared (betaxolol, levobunolol between 1985 and 1990, and the timolol-pilocarpine association between 1990 and 1995). After 1995, we saw the arrival of a new class of prostaglandin F2 alpha analogues, with latanoprost and other carbonic acid anhydrase inhibitors such as dorzolamide and brinzolamide.Conclusions: This study illustrates the great variety of glaucoma diagnostic subgroups and the use of surgery and drug therapies.
