A Fast, Powerful Method for Detecting Identity by Descent
A Fast, Powerful Method for Detecting Identity by Descent
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DOI：
10.1016/j.ajhg.2011.01.010
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发表时间：
2011-02-11
影响因子：
9.8
通讯作者：
Browning, Sharon R.
中科院分区：
文献类型：
--
作者：
Browning, Brian L.;Browning, Sharon R.
我们提出了一种方法，fastIBID，通过下降（IBD）对个人之间的身份发现道。FastIBD可以应用于全基因组SNP数据中的数千个样本，并且在寻找IBD的短片段方面比现有的在此类数据中寻找IBD片段的方法更强大。我们表明，fastIBD可以检测人口结构的方面，没有透露其他方法。在Wellcome Trust Case Control Consortium双相情感障碍病例对照数据中，我们发现与对照组相比，病例对个体中IBD的基因组范围内过量。我们发现，这种过度可以解释的地理聚集的情况下。我们还表明，它是可以使用快速！BD生成对远亲之间全基因组IBD共享的高度准确的估计。这对于关联研究中的关系估计和相关性调整是有用的。FastIBD包含在免费提供的Beagle软件包中。
We present a method, fastIBID, for finding tracts of identity by descent (IBD) between pairs of individuals. FastIBD can be applied to thousands of samples across genome-wide SNP data and is significantly more powerful for finding short tracts of IBD than existing methods for finding IBD tracts in such data. We show that fastIBD can detect facets of population structure that are not revealed by other methods. In the Wellcome Trust Case Control Consortium bipolar disorder case-control data, we find a genome-wide excess of IBD in case-case pairs of individuals compared to control-control pairs. We show that this excess can be explained by the geographical clustering of cases. We also show that it is possible to use fast! BD to generate highly accurate estimates of genome-wide IBD sharing between pairs of distant relatives. This is useful for estimation of relationship and for adjusting for relatedness in association studies. FastIBD is incorporated in the freely available Beagle software package.