Effect of surrounding tissue on vessel fluid and solid mechanics
Effect of surrounding tissue on vessel fluid and solid mechanics
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DOI：
10.1115/1.1824128
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发表时间：
2004-12-01
影响因子：
1.7
通讯作者：
Kassab, GS
中科院分区：
文献类型：
--
作者：
Zhang, W;Herrera, C;Kassab, GS
动脉粥样硬化是西方社会最重要的健康问题之一。动脉粥样硬化与异常的应激和紧张状态有关，这是公认的。一个令人信服的观察结果是心外膜动脉发生动脉粥样硬化，而壁内动脉则不会。涉及冠状动脉的心外膜部分的动脉粥样硬化改变在动脉穿透心肌处停止。本研究的目的是了解两种类型的血管之间的流体和固体力学差异。采用有限元方法研究了外部组织收缩对脉动血流特性和血管壁应力分布的影响。顺序耦合（如果流固相互作用（FSI））表明，流速和壁面剪应力的变化，响应于周期性的外部负载，出现比周向应力和应变减少在血管壁的建议的边界条件下的重要性。这些结果具有重要的意义，因为高应力和应变可以诱导生长，重塑和动脉粥样硬化，因此我们推测，应力和应变的减少可能是动脉粥样硬化保护。FSI在脉动流变形血管中的重要性进行了讨论，并强调了心外膜和壁内血管之间的流体和固体力学差异。
There is no doubt that atherosclerosis is one of the most important health problems in the Western Societies. It is well accepted that atherosclerosis is associated with abnormal stress and strain conditions. A compelling observation is that the epicardial arteries develop atherosclerosis while the intraimural arteries do not. Atherosclerotic changes involving the epicardial portion of the coronary artery stop where the artery penetrates the myocardium. The objective of the present study is to understand the fluid and solid mechanical differences between the two types of vessels. A finite element analysis was employed to investigate the effect of external tissue contraction on the characteristics of pulsatile blood flow and the vessel wall stress distribution. The sequential coupling (if fluid-solid interaction (FSI) revealed that the changes of flow velocity and wall shear stress, in response to cyclical external loading, appear less important than the circumferential stress and strain reduction in the vessel wall under the proposed boundary conditions. These results have important implications since high stresses and strains can induce growth, remodeling, and atherosclerosis; and hence we speculate that a reduction of stress and strain may be atheroprotective. The importance of FSI in deformable vessels with pulsatile flow is discussed and the fluid and solid mechanics differences between epicardiol and intramural vessels are highlighted.