Tobacco smoke and bladder cancer-in the European prospective investigation into cancer and nutrition
Tobacco smoke and bladder cancer-in the European prospective investigation into cancer and nutrition
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DOI：
10.1002/ijc.22169
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发表时间：
2006-11-15
影响因子：
6.4
通讯作者：
Riboli, Elio
中科院分区：
文献类型：
--
作者：
Bjerregaard, Bine Kjoller;Raaschou-Nielsen, Ole;Riboli, Elio
本研究的目的是探讨吸烟与膀胱癌发生的关系。研究人群包括429,906名参与欧洲癌症与营养前瞻性调查(EPIC)的人，其中633人在随访期内患上膀胱癌。与从不吸烟的人相比，目前吸烟者(发病率比3.96，95%可信区间：3.07-5.09)和既往吸烟者(2.25，1.74-2.91)患膀胱癌的风险都有所增加。在当前吸烟者中，发现与吸烟强度(每5支香烟)呈正相关(1.18，1.09-1.28)。观察持续时间(1.14，1.08-1.21)、开始年龄(0.75，0.66-0.85)和戒烟后较长时间(0.92，0.86-0.98)的联想(每5年一次)。儿童时期暴露于环境烟草烟雾(ETS)会增加患膀胱癌的风险(1.38，1.00-1.90)，而成年后暴露于ETS则没有检测到影响。目前的研究证实了吸烟和膀胱癌之间的密切联系。那些在很小的时候就开始吸烟的人和那些在童年时期暴露于ETS的人患膀胱癌的风险更高，这一迹象增加了表明儿童比成年人对致癌物更敏感的证据。(C)2006年Wiley-Liss，Inc.
The purpose of the present study was to investigate the association between smoking and the development of bladder cancer. The study population consisted of 429,906 persons participating in the European Prospective Investigation into Cancer and Nutrition (EPIC), 633 of whom developed bladder cancer during the follow-up period. An increased risk of bladder cancer was found for both current- (incidence rate ratio 3.96, 95% confidence interval: 3.07-5.09) and ex- (2.25, 1.74-2.91) smokers, compared to never-smokers. A positive association with intensity (per 5 cigarettes) was found among current-smokers (1.18, 1.09-1.28). Associations (per 5 years) were observed for duration (1.14, 1.08-1.21), later age at start (0.75, 0.66-0.85) and longer time since quitting (0.92, 0.86-0.98). Exposure to environmental tobacco smoke (ETS) during childhood increased the risk of bladder cancer (1.38, 1.00-1.90), whereas for ETS exposure as adult no effect was detected. The present study confirms the strong association between smoking and bladder cancer. The indication of a higher risk of bladder cancer for those who start smoking at a young age and for those exposed to ETS during childhood adds to the body of evidence suggesting that children are more sensitive to carcinogens than adults. (c) 2006 Wiley-Liss, Inc.