Expert Opinion: Efficacy of superficial chemical peels in active acne management - what can we learn from the literature today? Evidence-based recommendations
Expert Opinion: Efficacy of superficial chemical peels in active acne management - what can we learn from the literature today? Evidence-based recommendations
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DOI：
10.1111/j.1468-3083.2010.03852.x
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发表时间：
2011-06-01
影响因子：
9.2
通讯作者：
Wang, B.
中科院分区：
文献类型：
--
作者：
Dreno, B.;Fischer, T. C.;Wang, B.
背景浅层化学剥脱术提供了一种方便、经济的治疗方法。许多临床医生在治疗痤疮和易生粉刺的油性皮肤时使用这种脱皮。目的本文考察了支持在这种环境中广泛使用浅层脱皮的证据基础。方法检索英文医学文献，以确定正式评估化学脱皮在活动性痤疮中的使用的临床试验。结果检索文献显示，脱皮治疗痤疮的临床试验很少(N=13)；大多数试验包括少数患者，没有对照，并且是开放标签的。现有的证据确实支持在痤疮中使用化学脱皮，因为所有试验都取得了总体上有利的结果，尽管评估、治疗方案和患者群体存在差异。值得注意的是，还没有关于化学去角质的研究使用痤疮药物作为对比。由于并不是所有的出版物都明确规定是否允许同时使用痤疮药物，因此很难清楚地评估有多少研究评估了单独剥皮的效果。然而，这可能是适当的，因为很少有临床医生会将浅层化学脱皮作为痤疮的唯一治疗方法，除非在极少数情况下患者无法耐受其他治疗方式。结论在未来，需要进一步的研究来确定化学脱皮在这一适应症中的最佳使用。
BackgroundSuperficial chemical peels offer therapeutic results in a convenient, affordable treatment. Many clinicians use these peels in the treatment of acne and acne-prone oily skin.ObjectivesThis article examines the evidence base that supports the widespread use of superficial peels in this setting.MethodsA search of the English language medical literature was performed to identify clinical trials that formally evaluated the use of chemical peeling in active acne.ResultsSearch of the literature revealed very few clinical trials of peels in acne (N = 13); a majority of these trials included small numbers of patients, were not controlled and were open label. The evidence that is available does support the use of chemical peels in acne as all trials had generally favourable results despite differences in assessments, treatment regimens and patient populations. Notably, no studies of chemical peels have used an acne medication as a comparator. As not every publication specified whether or not concomitant acne medications were allowed, it is hard to evaluate clearly how many of the studies evaluated the effect of peeling alone. This may be appropriate, however, given that few clinicians would use superficial chemical peels as the sole treatment for acne except in rare instances where a patient could not tolerate other treatment modalities.ConclusionsIn the future, further study is needed to determine the best use of chemical peels in this indication.