Characterizing a new tool to manipulate area postrema GLP1R+ neurons across species.
Characterizing a new tool to manipulate area postrema GLP1R+ neurons across species.
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描述一种跨物种操纵后区 GLP1R 神经元的新工具。
DOI：
10.1016/j.physbeh.2024.114474
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发表时间：
2024
影响因子：
2.9
通讯作者：
Zhang,Chuchu
中科院分区：
文献类型：
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作者：
Fulton,Stephanie;Horn,CharlesC;Zhang,Chuchu
恶心是伴随许多治疗的不舒服感觉，尤其是涉及胰高血糖素样肽-1受体（GLP 1 R）激动剂的糖尿病治疗。最近对小鼠的研究表明，最后区的GLP 1 R表达神经元在恶心中起着关键作用。在这里，我们的特点是配体共轭皂草素，可以有效地消融GLP 1 R+细胞从人类，小鼠，和theSuncus murinus，一个小动物模型能够呕吐。这种新的工具提供了一种策略来操纵特定的神经通路在theSuncus murinus最后区，并可能有助于阐明的作用，最后区GLP 1 R+神经元在呕吐治疗涉及GLP 1 R激动剂。
Nausea is an uncomfortable sensation that accompanies many therapeutics, especially diabetes treatments involving glucagon-like peptide-1 receptor (GLP1R) agonists. Recent studies in mice have revealed that GLP1R-expressing neurons in the area postrema play critical roles in nausea. Here, we characterized a ligand-conjugated saporin that can efficiently ablate GLP1R+cells from humans, mice, and theSuncus murinus, a small animal model capable of emesis. This new tool provides a strategy to manipulate specific neural pathways in the area postrema in theSuncus murinusand may help elucidate roles of area postrema GLP1R+neurons in emesis during therapeutics involving GLP1R agonists.