Activation of Agrp neurons modulates memory-related cognitive processes in mice.
Activation of Agrp neurons modulates memory-related cognitive processes in mice.
复制标题
Agrp 神经元的激活调节小鼠记忆相关的认知过程。
DOI：
10.1016/j.phrs.2018.12.024
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发表时间：
2019
影响因子：
9.3
通讯作者：
Dietrich,MarceloO
中科院分区：
文献类型：
--
作者：
Zimmer,MarceloR;Schmitz,ArianaE;Dietrich,MarceloO
下丘脑Agrp神经元是成年小鼠摄食的关键调节因子。除了食物摄入，这些神经元还参与其他认知过程，例如刻板行为的表现。在这里，我们评估了Agrp神经元在空间记忆相关任务中调节小鼠行为的程度。我们发现，激活的Agrp神经元不影响空间学习，但改变了行为的灵活性，使用修改版本的巴恩斯迷宫任务。此外，使用Y-迷宫测试来探测工作记忆，我们发现Agrp神经元的化学发生激活减少了由神经肽Y受体-5信号传导介导的自发交替行为。这些发现表明Agrp神经元在记忆相关的认知过程中具有新的功能特性。
Hypothalamic Agrp neurons are critical regulators of food intake in adult mice. In addition to food intake, these neurons have been involved in other cognitive processes, such as the manifestation of stereotyped behaviors. Here, we evaluated the extent to which Agrp neurons modulate mouse behavior in spatial memory-related tasks. We found that activation of Agrp neurons did not affect spatial learning but altered behavioral flexibility using a modified version of the Barnes Maze task. Furthermore, using the Y-maze test to probe working memory, we found that chemogenetic activation of Agrp neurons reduced spontaneous alternation behavior mediated by the neuropeptide Y receptor-5 signaling. These findings suggest novel functional properties of Agrp neurons in memory-related cognitive processes.