The effects of resistance training on bone mineral density and bone quality in type 2 diabetic rats
The effects of resistance training on bone mineral density and bone quality in type 2 diabetic rats
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DOI：
10.14814/phy2.14046
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发表时间：
2019-03-01
影响因子：
2.5
通讯作者：
Imai, Yuuki
中科院分区：
文献类型：
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作者：
Ikedo, Aoi;Kido, Kohei;Imai, Yuuki
众所周知，阻力训练 (RT) 可有效维持和提高骨强度，骨强度基于骨矿物质密度 (BMD) 和骨质量。然而，对于骨折风险较高的 2 型糖尿病 (T2DM) 患者，RT 是否能有效提高骨强度尚不清楚。因此，我们在 T2DM 模型大鼠（雄性 Otsuka Long-Evans Tokushima Fatty (OLETF) 及其对照 Long-Evans Tokushima Otsuka (LETO)）中测试了使用经皮电刺激的 6 周 RT 方案的效果。 RT 6 周后，两组 RT 腿的胫骨 BMD 均显着高于对照 (CON) 腿。在骨干皮质骨中，与 CON 腿相比，两组 RT 腿的骨面积/组织面积和皮质厚度均显着增加。与 LETO 相比，OLETF 中观察到的皮质孔隙度较高，但 RT 改善了两组的皮质孔隙度。有趣的是，与 CON 腿相比，RT 腿的小梁数量、小梁厚度和小梁间隙以及 BMD 和近端胫骨干骺端小梁骨的骨体积/组织体积均显着改善。相反，连接密度和结构模型指数不受RT影响。这些结果表明，6 周 RT 方案有效增加了 T2DM 模型大鼠和对照大鼠的 BMD 并改善了骨质量。因此，即使对于 T2DM 患者，RT 也有可能提高骨强度并降低骨折风险。
Resistance training (RT) has been known to be effective in maintaining and improving bone strength, which is based on bone mineral density (BMD) and bone quality. However, it is not clear whether RT is effective in improving bone strength in patients with type-2 diabetes mellitus (T2DM), who have a high risk of fracture. Therefore, we tested the effects of a 6-week RT regimen using percutaneous electrical stimulation in T2DM model rats, male Otsuka Long-Evans Tokushima Fatty (OLETF), and its control, Long-Evans Tokushima Otsuka (LETO). After 6 weeks of RT, tibial BMD in RT legs was significantly higher than that in control (CON) legs in both groups. In diaphyseal cortical bone, bone area/tissue area, and cortical thickness was significantly increased in RT legs compared with CON legs in both groups. Cortical porosity was highly observed in OLETF compared with LETO, but RT improved cortical porosity in both groups. Interestingly, trabecular number, trabecular thickness and trabecular space as well as BMD and bone volume/tissue volume in proximal tibial metaphyseal trabecular bone were significantly improved in RT legs compared with CON legs in both groups. In contrast, connectivity density and structural model index were not affected by RT. These results indicate that the 6-week RT regimen effectively increased BMD and improved bone quality in T2DM model rats as well as control rats. Therefore, RT may have the potential to improve bone strength and reduce fracture risk, even in patients with T2DM.