Is the spatial distribution of brain lesions associated with closed-head injury predictive of subsequent development of attention-deficit/hyperactivity disorder? Analysis with brain-image database?
Is the spatial distribution of brain lesions associated with closed-head injury predictive of subsequent development of attention-deficit/hyperactivity disorder? Analysis with brain-image database?
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DOI：
10.1148/radiology.213.2.r99nv45389
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发表时间：
1999-11-01
期刊：
影响因子：
19.7
通讯作者：
Gerring, JP
中科院分区：
文献类型：
--
作者：
Herskovits, EH;Megalooikonomou, V;Gerring, JP
目的：探讨儿童闭合性脑损伤后磁共振(MR)检查发现的病变空间分布与继发性注意缺陷/多动障碍(ADHD)的关系。材料与方法：对76例无ADHD既往病史的儿童进行分析。闭合性颅脑损伤后3个月行MRI检查。在手工勾画病变后，图像被配准到Talairach坐标系。对于每个受试者，注册的图像和二次ADHD状态被整合到一个脑图像数据库中，该数据库包含描述(可视化)和统计分析软件。利用这个数据库，我们直观地评估了病变的空间分布，并对图像和临床变量进行了统计分析。结果：在76名儿童中，15名发展为继发性ADHD。对数据的描述表明，患有继发性ADHD的儿童右侧壳核的病变比没有发展为继发性ADHD的儿童更多；这一印象在统计上得到了证实。Bonferroni矫正后，右侧尾状核或右侧苍白球的继发性ADHD状态与损害负担之间无显著差异。结论：儿童闭合性头部损伤所致右侧壳核损害与继发性ADHD的发生有关。描述软件在指导图像数据的统计分析方面很有用。
PURPOSE: To determine whether there is an association between the spatial distribution of lesions detected at magnetic resonance (MR) imaging of the brain in children after closed-head injury and the development of secondary attention-deficit/hyperactivity disorder (ADHD).MATERIALS AND METHODS: Data obtained from 76 children without prior history of ADHD were analyzed. MR images were obtained 3 months after closed-head injury. After manual delineation of lesions, images were registered to the Talairach coordinate system. For each subject, registered images and secondary ADHD status were integrated into a brain-image database, which contains depiction (visualization) and statistical analysis software. Using this database, we assessed visually the spatial distributions of lesions and performed statistical analysis of image and clinical variables.RESULTS: Of the 76 children, 15 developed secondary ADHD. Depiction of the data suggested that children who developed secondary ADHD had more lesions in the right putamen than children who did not develop secondary ADHD; this impression was confirmed statistically. After Bonferroni correction, we could not demonstrate significant differences between secondary ADHD status and lesion burdens for the right caudate nucleus or the right globus pallidus.CONCLUSION: Closed-head injury-induced lesions in the right putamen in children are associated with subsequent development of secondary ADHD. Depiction software is useful in guiding statistical analysis of image data.