Antimicrobial resistance of Staphylococcus aureus isolated from skin infections.
Antimicrobial resistance of Staphylococcus aureus isolated from skin infections.
复制标题
从皮肤感染中分离出的金黄色葡萄球菌的耐药性。
DOI：
10.1016/s0924-8579(01)00496-4
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发表时间：
2002
影响因子：
10.8
通讯作者：
I. Kurokawa
中科院分区：
文献类型：
--
作者：
S. Nishijima;I. Kurokawa
用琼脂稀释法测定了从各种皮肤感染中分离的229株金黄色葡萄球菌对22种抗菌药物的敏感性。临床分离株对万古霉素、替考拉宁、莫匹罗星、呋西地酸最敏感。没有菌株对万古霉素或替考拉宁耐药。3株对莫匹罗星高度耐药(MIC100 mg/L)，8株对呋西地酸高度耐药(MIC、≥为100 mg/L)。除庆大霉素外，其余抗菌药物的MIC50均在3.13 mg/L以下，对青霉素、头孢菌素、克林霉素的耐药率为20%~30%。对庆大霉素、红霉素和罗红霉素的耐药率较高，分别为55.2%、39.6%和39.1%。21.0%的菌株对甲氧西林耐药。≥为3.13 mg/L的细菌对苯唑西林的耐药率为24.3%。这些结果与日本皮肤病标本中MRSA的平均比率相当。
The antimicrobial susceptibility of 229 strains of Staphylococcus aureus isolated from various skin infections was determined against 22 antimicrobial agents by the agar dilution method. The clinical isolates were most sensitive to vancomycin, teicoplanin, mupirocin and fusidic acid. No strains were resistant to vancomycin or teicoplanin. Three strains were highly resistant (MIC ≥100 mg/l) to mupirocin and eight strains to fusidic acid. The MIC50of all antimicrobials, except for gentamicin, were below 3.13 mg/l. The incidence of resistance to penicillin, cephalosporins and clindamycin ranged from 20 to 30%. The occurrence of gentamicin, erythromycin and roxithromycin resistance was high at 55.2, 39.6 and 39.1%, respectively. Methicillin resistance occurred in 21.0% of strains. The incidence of organisms with MIC ≥3.13 mg/l to oxacillin was 24.3%. These results were comparable to the average rate of MRSA in Japanese dermatological specimens.