Prevalence of Congenital Heart Disease in Xinjiang Multi-Ethnic Region of China.
Prevalence of Congenital Heart Disease in Xinjiang Multi-Ethnic Region of China.
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DOI：
10.1371/journal.pone.0133961
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Gao XM
中科院分区：
文献类型：
--
作者：
Liu F;Yang YN;Xie X;Li XM;Ma X;Fu ZY;Chen BD;Huang Y;Shan CF;Ma YT;Gao XM
目前，新疆地区先天性心脏病患病率及危险因素尚不清楚。本研究采用多民族、以社区为基础的横断面研究，对新疆地区先天性心脏病（CHD）的患病率和分布进行了评估。2010年2月至2012年5月对该地区维吾尔族、汉族、哈萨克族和回族四个主要民族的儿童进行了调查。共检查了14530名儿童（0-18岁）。其中，240名儿童（男孩43.8%，女孩56.3%）被诊断为冠心病，总体患病率为16.5‰（维吾尔族17.7‰，汉族6.9‰，哈萨克族11.4‰，回族38.1‰）。室间隔缺损（VSD, 29.2%）、房间隔缺损（ASD, 20.8%）、动脉导管未闭（PDA, 13.7%）、心功能不全（13.7%）、二尖瓣主动脉瓣（7.9%）、肺动脉瓣狭窄（5.4%）和法洛四联症（TOF, 4.2%）是常见的青紫型和青紫型缺陷。与非冠心病患儿相比，冠心病患儿流产史、家族史、血亲史、早产率均高于非冠心病患儿（P<0.05）。在CHD儿童中，24%的母亲在妊娠前三个月患过感冒，10%的母亲患有发热性疾病，6.7%的母亲接受过抗生素治疗，高于非CHD组（均P<0.05）。新疆4个民族0 ~ 18岁儿童冠心病总患病率为16.5‰。VSD、ASD和TOF分别是最常见的无紫型和紫绀型先天性心脏缺陷。本研究还确定了一些可改变的危险因素，这些因素可能导致4个民族的冠心病发病率。
The prevalence and risk factors of congenital heart disease among Xinjiang, northwestern part of China is currently unknown. This multiple-ethnic, community-based, cross-sectional study was conducted to estimate the prevalence and distribution of congenital heart disease (CHD) in Xinjiang, northwestern part of China. Four major ethnics, Uygur, Han, Kazak, and Hui children in this region were investigated during February 2010 and May 2012. A total of 14,530 children (0–18 yr) were examined. Of these children, 240 (boys, 43.8%, and girls, 56.3%) were identified with CHD, giving an overall prevalence of 16.5‰ (17.7‰ in Uygur, 6.9‰ in Han, 11.4‰ in Kazak, and 38.1‰ in Hui Chinese, respectively). Ventricular septal defect (VSD, 29.2%), atrial septal defect (ASD, 20.8%), patent ductus arteriosus (PDA, 13.7%), acleistocardia (13.7%), Bicuspid aortic valve (7.9%), pulmonary valve stenosis (5.4%), and tetralogy of fallot (TOF, 4.2%) were common cyanotic and cyanotic defects observed. Compared to non-CHD children, children with CHD had a higher percentage of history of abortion, CHD history of family, consanguinity and premature birth (all P<0.05). In CHD children, 24% of mothers caught a cold, 10% had a febrile illness and 6.7% received antibiotic treatment during the first trimester of pregnancy, that were higher than non-CHD group (all P<0.05). The overall prevalence of CHD in four ethnic children at ages 0–18 yr in Xinjiang was 16.5‰. VSD, ASD and TOF were the most common acyanotic and cyanotic congenital heart defects, respectively. This study also identified some modifiable risk factors that may contribute to the incidence of CHD among the 4 ethnic groups.