A computational framework to quantify tissue microstructural integrity using conventional MRI macrostructural volumetry.
A computational framework to quantify tissue microstructural integrity using conventional MRI macrostructural volumetry.
复制标题
使用传统 MRI 宏观结构体积法量化组织微观结构完整性的计算框架。
DOI：
10.1016/j.compbiomed.2010.10.009
复制
发表时间：
2011
影响因子：
7.7
通讯作者：
Hasan,KhaderM
中科院分区：
文献类型：
--
作者：
Walimuni,IndikaS;Abid,Humaira;Hasan,KhaderM
在这项工作中，我们提出了一个框架，融合和量化组织的微观结构属性（如扩散，功能，弛豫和灌注MRI）使用高空间分辨率T1加权体积测量。所提出的计算过程可以通过利用先进的图像分割、配准和扩散张量图像处理软件来实现。该框架的可行性也证明了使用内部开发的软件和免费提供的软件，如FreeSurfer的区域组织分割，高级归一化工具（ANT）的注册和DTISudio的纤维跟踪和扩散张量数据处理。我们还证明了这些方法在提供质量控制措施，以评估组织分割和多模态MRI配准的保真度的应用。
In this work, we present a framework to fuse and quantify tissue microstructural attributes (e.g. diffusion, functional, relaxation and perfusion MRI) using high spatial resolution T1-weighted volumetric measurements. The proposed computational procedures can be implemented by utilizing advanced, image segmentation, registration and diffusion tensor image processing software. Feasibility of the framework is also demonstrated using in-house developed software and freely available software such as FreeSurfer for regional tissue segmentation, Advanced Normalization Tools (ANTs) for registration and DTIStudio for fiber tracking and diffusion tensor data processing. We also demonstrate the application of these methods in the provision of quality control measures to assess the fidelity of tissue segmentation and multi-modal MRI registration.