Changes in bombesin, calcitonin, and serotonin immunoreactive pulmonary neuroendocrine cells in cystic fibrosis and after prolonged mechanical ventilation.
Changes in bombesin, calcitonin, and serotonin immunoreactive pulmonary neuroendocrine cells in cystic fibrosis and after prolonged mechanical ventilation.
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囊性纤维化和长期机械通气后蛙皮素、降钙素和血清素免疫反应性肺神经内分泌细胞的变化。
DOI：
10.1164/ajrccm/137.1.123
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Landrum,BG
中科院分区：
文献类型：
--
作者：
Johnson,DE;Wobken,JD;Landrum,BG
铃贝素、降钙素和血清素的增加已在患有支气管肺发育不良的婴儿中记录到免疫反应性肺神经内分泌细胞。由于已知这些假定的气道化学感受器的一些分泌产物会对肺血管舒缩和支气管运动张力产生不利影响，因此进行本研究以确定患有慢性呼吸道疾病的老年儿科患者的肺部是否发生类似的变化。使用抗体-过氧化物酶-抗过氧化物酶技术鉴定免疫反应性细胞，并将其表达为肺组织的免疫反应性细支气管lcm2。在因意外或非心肺死亡而死亡的受试者中（对照组：n = 48，0 至 24 岁），铃蟾肽、降钙素和血清素免疫反应性细支气管 Icm2 的总数在出生时最高，然后在生命第一年后迅速下降至极低水平。在囊性纤维化（n = 55，3 天至 29 岁）和长期通气（en = 24，4 个月至 18 岁）组中，铃贝素、降钙素和血清素免疫反应性支气管显着增加（p < 0.035）
Increases In bombesln, calcitonin, and serotonin Immunoreactive pulmonary neuroendocrine cells have been documented In Infants with bronchopulmonary dysplasia. As some of the secretory products of these postulated airway chemoreceptons are known to advenselyaffect pUlmonary vasomotor and bronchomotor tone, the present study was undertaken to determine Ifsimi-lar changes occur In the lungs of older pediatric patients with chronic respiratory disease. Immunoreactive cells were Identified using the antlbody-peroxldase-antlperoxldase technique and expressed as Immunoreactive bronchloleslcm2 of lung tissue. In subjects dying an accidental or noncardlopulmonary death (control group: n= 48, zero to 24 yr of age), the totel number of bombesin, calcitonin, and serotonin Immunoreactive bronchiolesIcm2 was greatest at birth, then decreased rapidly to extremely low levels after the first year of life. In the cystic fibrosis (n= 55, 3 days to29 yr of age) and prolonged ventilation en= 24, 4 months to 18 yr of age) groups, there was a significant Increase (p< 0.035) In bombesln, calcitonin, and serotonin Immunoreactive bronchi-