Cell-cell communication in gram-negative bacteria
Cell-cell communication in gram-negative bacteria
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DOI：
10.1039/b505796p
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发表时间：
2005-09-01
影响因子：
--
通讯作者：
Spring, DR
中科院分区：
文献类型：
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作者：
Welch, M;Mikkelsen, H;Spring, DR
在过去十年左右的时间里，大量的研究已经证实，细菌之间使用小分子进行交流。这些信号使种群中的个体能够协调他们的行为。在病原体的情况下，这一行为可能包括诸如何时攻击宿主生物体或形成生物膜的决定。因此，这种信号系统是开发新的抗菌疗法的极佳靶点。在这篇综述中，我们评估了革兰氏阴性细菌如何使用小分子进行细胞间通信，并讨论了已经开发的干预它的主要方法。
Over the last decade or so, a wealth of research has established that bacteria communicate with one another using small molecules. These signals enable the individuals in a population to coordinate their behaviour. In the case of pathogens, this behaviour may include decisions such as when to attack a host organism or form a biofilm. Consequently, such signalling systems are excellent targets for the development of new antibacterial therapies. In this review, we assess how Gram-negative bacteria use small molecules for cell-cell communication, and discuss the main approaches that have been developed to interfere with it.