Clinical investigation of amelanotic malignant melanoma in the oral region
Clinical investigation of amelanotic malignant melanoma in the oral region
复制标题
DOI：
10.1016/j.joms.2004.01.017
复制
发表时间：
2004-08-01
影响因子：
1.9
通讯作者：
Amagasa, T
中科院分区：
文献类型：
--
作者：
Tanaka, N;Mimura, M;Amagasa, T
目的：无色性口腔恶性黑色素瘤（AOMM）是一种罕见的、难以诊断的肿瘤。我们研究了9例该肿瘤的临床和病理特征，以确定2种不同类型AOMM的诊断标准和预后。患者与方法：1970年至2002年间，对2种不同类型的9例原发性AOMM进行了检查。研究手术标本的组织病理学，免疫组织化学反应支持不确定的诊断，并回顾电子显微镜和预后。结果：没有放射状生长期的AOMM在没有免疫组织化学辅助的情况下可能特别难以正确诊断。在有和没有径向生长期的肿瘤中，多角形细胞和梭形细胞的比例不同。生存期从3个月到6年3个月不等，9例患者均死于肿瘤。9例中有7例发现远处转移。结论：无放射状生长期的AOMM易误诊为脓包癌或鳞状细胞癌。可疑病变，特别是上颌和腭病变，必须进行组织病理学活检和可能的免疫组织化学检查，然后进行快速治疗。AOMM预后较差。(C) 2004美国口腔颌面外科医师协会。
Purpose: Amelanotic oral malignant melanoma (AOMM) is a rare tumor that is difficult to diagnose. We studied the clinical and pathologic features of nine cases of this tumor to define diagnostic criteria and estimate prognoses for 2 different types of AOMM.Patients and Methods: Nine patients with 2 different types of primary AOMM were examined between 1970 and 2002. The histopathology of surgical specimens was Studied, uncertain diagnoses were supported by immunohistochemical reactions, and electron microscopy and prognoses were reviewed retrospectively.Results: AOMM without radial growth phase may be particularly difficult to diagnose correctly without immunohistochemical assistance. Tumors consisted of a mixture of polygonal and spindle cells in different ratios in tumors with and without radial growth phase. The life span ranged from 3 months to 6 years 3 months, and all 9 patients died of the tumor. In 7 of the 9 cases, distant metastases were found.Conclusions: AOMM without radial growth phase may be misdiagnosed as epulis or squamous cell carcinoma. Questionable lesions, particularly maxillary and palatal lesions, must be biopsied for histopathologic and possibly immunohistochemical examinations followed by rapid treatment. The prognosis of AOMM was poor. (C) 2004 American Association of Oral and Maxillofacial Surgeons.