Reduced threshold for cortical spreading depression in female mice
Reduced threshold for cortical spreading depression in female mice
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DOI：
10.1002/ana.21138
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发表时间：
2007-06-01
影响因子：
11.2
通讯作者：
Charles, Andrew C.
中科院分区：
文献类型：
--
作者：
Brennan, Kevin C.;Romero Reyes, Marcela;Charles, Andrew C.
女性偏头痛的患病率远高于男性。皮质扩散性抑制（CSD）被认为是偏头痛的基本机制，啮齿类动物的 CSD 被用作偏头痛的模型。我们使用光学内在信号成像和电生理学技术来研究 C57B1/6 小鼠的 CSD。使用两种不同的 CSD 诱导方法，我们发现与雄性小鼠相比，雌性小鼠的 CSD 诱导阈值显着降低。这些结果表明雌性小鼠的皮质兴奋性增加，这可能与动情周期无关。
The prevalence of migraine is much greater in female than male individuals. Cortical spreading depression (CSD) is thought to be a fundamental mechanism of migraine, and CSD in rodents is used as a model for migraine. We used optical intrinsic signal imaging and electrophysiological techniques to investigate CSD in C57B1/6 mice. Using two different methods for induction of CSD, we found that female mice had a significantly reduced threshold for induction of CSD compared with male mice. These results suggest an increased cortical excitability in female mice that may be independent of the estrous cycle.