Oxidative Stress
Oxidative Stress
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DOI：
10.1007/978-981-15-4501-6_164-1
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
N. Radharani;Ipsit Kundu;A. Yadav;Gopal C. Kundu
中科院分区：
文献类型：
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作者：
N. Radharani;Ipsit Kundu;A. Yadav;Gopal C. Kundu
氧化应激是氧化还原失衡的产物，在这种失衡中，体内自由基的增强会导致组织损伤。活性氧是乳腺癌中最重要的自由基，可通过缺氧、代谢改变和药物治疗等多种条件产生。ROS通过诱导DNA损伤和上调多种细胞存活和致癌途径，在乳腺肿瘤的发生和发展中发挥关键作用。较高的氧化应激可通过调节乳腺肿瘤微环境中促转移因子和促血管生成因子的表达，抑制抗氧化防御血管生成和转移。ROS也是癌症代谢改变的产物和关键调节因子。此外，氧化应激还通过诱导乳腺癌多种药物转运蛋白的表达与化疗耐药相关。这些过程在乳腺癌的发生发展中起着至关重要的作用。在本章中，我们讨论了自由基作为氧化应激的前体，以及氧化应激在乳腺癌进展、转移、血管生成、代谢重编程和耐药中的作用，以便更好地确定氧化还原依赖性乳腺癌治疗的潜在靶点。
Oxidative stress is a product of redox imbalance in which there is an enhancement of free radicals in the body which can cause tissue damage. ROS is the most important free radical species which can be generated in breast cancer by various conditions such as hypoxia, altered metabolism, and drug treatment. ROS perform a pivotal role in breast tumor initiation and progression by inducing DNA damage and upregulating various cell survival and oncogenic pathways. Higher oxidative stress can inhibit antioxidant defense against angiogenesis and metastasis by regulating the expression of pro-metastatic and pro-angiogenic factors in breast tumor microenvironment. ROS is also a product and key regulator of altered cancer metabolism. Furthermore, oxidative stress is also associated with chemotherapeutic drug resistance by inducing the expression of various drug transporters in breast cancer. These processes play critical role in the development and progression of breast cancer. In this chapter, we have discussed free radicals as precursors of oxidative stress and the role of oxidative stress in breast cancer progression, metastasis, angiogenesis, metabolic reprogramming, and drug resistance for better identification of the potential targets for redox dependent breast cancer therapy.