INTRAFAMILIAL CLUSTERING OF HELICOBACTER-PYLORI INFECTION
INTRAFAMILIAL CLUSTERING OF HELICOBACTER-PYLORI INFECTION
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DOI：
10.1056/nejm199002083220603
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发表时间：
1990-02-08
影响因子：
158.5
通讯作者：
SHERMAN, PM
中科院分区：
文献类型：
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作者：
DRUMM, B;PEREZPEREZ, GI;SHERMAN, PM
幽门螺杆菌（以前称为幽门弯曲杆菌）在胃窦的定植与原发性胃炎有关。我们测定了H. 93例儿童胃镜检查胃窦活检标本中幽门螺杆菌的检出率。我们还确定了H。通过酶联免疫吸附试验检测这些儿童、家庭成员和年龄相当的对照受试者的编码血清样本中的pylori IgG抗体水平。在27名患有原发性或不明原因胃炎的儿童中，H。通过银染色法和细菌培养法分别在24例和22例活检标本中发现了幽门螺杆菌，23例儿童（96%）发现了特异性抗体。3例不明原因胃炎患儿无H。13例继发性胃炎或53例胃窦组织学正常的患儿中均未检测到幽门螺杆菌抗体，69例患儿中仅1例检测到特异性抗体。H. 34例定植儿家长中有25例pylori抗体阳性，而33例非定植儿家长中仅8例pylori抗体阳性（P < 0.001）。对22名H. pylori抗体阳性者18例，对照组5例（P < 0.001）。我们的结论是H.幽门特异性IgG抗体与该生物体在胃窦的细菌定植有关。H.幽门螺杆菌感染表明这些细菌可能在人与人之间传播。
Colonization of the gastric antrum by Helicobacter pylori (formerly Campylobacter pylori) has been associated with primary gastritis. We determined the frequency of colonization by H. pylori in gastric-antrum biopsy specimens from 93 children undergoing gastroscopy for the evaluation of upper gastrointestinal symptoms. We also determined H. pylori IgG antibody levels by enzyme-linked immunosorbent assay in coded serum samples from these children, family members, and control subjects of comparable ages. Among 27 children with primary, or unexplained, gastritis, H. pylori was identified by silver staining in 24 biopsy specimens and by culture in 22; specific antibodies were present in 23 children (96 percent). Three children with unexplained gastritis had no evidence of H. pylori in the antrum, nor did any of 13 children with secondary gastritis or any of 53 children with normal antral histologic features; specific antibodies were present in only 1 of these 69 children. H. pylori antibody was detected in 25 of 34 parents of colonized children, but in only 8 of 33 parents of noncolonized children (P < 0.001). Of 22 siblings of children colonized by H. pylori, 18 had specific antibodies, as compared with only 5 of 37 controls (P < 0.001). We conclude that H. pylori-specific IgG antibodies are associated with bacterial colonization of the gastric antrum by this organism. The intrafamilial clustering of H. pylori infection suggests that there may be person-to-person spread of these bacteria.