Neuro-ophthalmologic evaluation, quality of life, and functional disability in patients with MS
Neuro-ophthalmologic evaluation, quality of life, and functional disability in patients with MS
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DOI：
10.1212/wnl.0b013e318299ccd9
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发表时间：
2013-07-02
期刊：
影响因子：
9.9
通讯作者：
Pablo, Luis E.
中科院分区：
文献类型：
--
作者：
Garcia-Martin, Elena;Rodriguez-Mena, Diego;Pablo, Luis E.
目的：利用光学相干断层扫描（OCT）、视觉诱发电位（VEP）和视野检查，评估多发性硬化（MS）患者神经眼科指标的纵向变化与生活质量（QOL）和残疾之间的相关性。方法：54例复发缓解型MS患者入组本研究，并接受多发性硬化生活质量问卷调查（54项）（MSQOL-54）和扩展残疾状态量表（EDSS）评估，以及完整的神经眼科检查，包括视野测试和使用Cirrus和Spectralis OCT和VEP的视网膜神经纤维层（RNFL）测量。在12、24和36个月时对所有患者进行重新评价。结果：总体而言，基线评估时RNFL厚度结果与3年时有显著差异（p
Objective: To evaluate correlations between longitudinal changes in neuro-ophthalmologic measures and quality of life (QOL) and disability in patients with multiple sclerosis (MS), using optical coherence tomography (OCT), visual evoked potentials (VEP), and visual field examination.Methods: Fifty-four patients with relapsing-remitting MS were enrolled in this study and underwent Multiple Sclerosis Quality of Life questionnaire (54 items) (MSQOL-54) and Expanded Disability Status Scale (EDSS) evaluation, as well as complete neuro-ophthalmologic examination including visual field testing and retinal nerve fiber layer (RNFL) measurements using Cirrus and Spectralis OCT and VEP. All patients were re-evaluated at 12, 24, and 36 months. Logistical regression was performed to analyze which measures, if any, could predict QOL.Results: Overall, RNFL thickness results at the baseline evaluation were significantly different from those at 3 years (p