Correlational analysis between neutrophil granulocyte levels and osteonecrosis of the femoral head
Correlational analysis between neutrophil granulocyte levels and osteonecrosis of the femoral head
复制标题
中性粒细胞水平与股骨头坏死的相关性分析
DOI：
10.1186/s12891-019-2778-7
复制
发表时间：
2019-08-31
影响因子：
2.3
通讯作者：
Li, Xiaofeng
中科院分区：
文献类型：
--
作者：
Jiang, Jiang;Liu, Xuqiang;Li, Xiaofeng
背景外周血中性粒细胞水平与股骨头坏死（osteonecrosis of femoral head，ONFH）的相关性尚未得到广泛研究。因此，我们的目的是探讨外周血中性粒细胞水平（中性粒细胞）和ONFH.MethodsA共984例ONFH和股骨颈骨折（非ONFH）诊断在骨科在我院2011年1月1日至2016年12月31日之间的相关性。ONFH和非ONFH组分别包括488和496例病例。结果患者年龄38-82岁，平均（59.89 ± 17.06）岁。男性457例，女性527例，男女比例为1：1.15。我们发现ONFH组和非ONFH组的中性粒细胞水平和中性粒细胞百分比有显著差异。多因素回归分析显示中性粒细胞百分比是影响ONFH的独立保护因素。结论影响ONFH的因素是中性粒细胞水平和中性粒细胞百分比。中性粒细胞百分比与股骨头无菌性坏死有显著相关性，为进一步研究股骨头坏死提供了新的视角和方向。
BackgroundThe correlation between peripheral blood neutrophil level and osteonecrosis of the femoral head (ONFH) has not been extensively studied. Thus, we aimed to investigate the correlation between neutrophil level in the peripheral blood (neutrophil granulocyte) and ONFH.MethodsA total of 984 cases of ONFH and femoral neck fractures (non-ONFH) diagnosed at the Department of Orthopedics at our institution between January 1, 2011 and December 31, 2016 were retrospectively reviewed. The ONFH and non-ONFH groups comprised 488 and 496 cases, respectively. Basic information and peripheral blood cell levels of the two groups were compared.ResultsThe patients’ mean age was 59.89 ± 17.06 years (range: 38–82 years). There were 457 male and 527 female patients, with a male-to-female ratio of 1:1.15. We found that neutrophil granulocyte levels and percentage of neutrophil granulocytes were significantly different between the ONFH and non-ONFH groups. Multimodal regression analysis showed that the percentage of neutrophil granulocytes was an independent protective factor against ONFH.ConclusionsThe factors influencing ONFH are neutrophil granulocyte levels and percentage of neutrophil granulocytes. Percentage of neutrophil granulocytes has a significant correlation with aseptic femoral head necrosis, providing a new perspective and direction for further study of femoral head necrosis.