Grip strength mediates the relationship between muscle mass and frailty
Grip strength mediates the relationship between muscle mass and frailty
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DOI：
10.1002/jcsm.12510
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发表时间：
2019-12-26
影响因子：
8.9
通讯作者：
Kim, Yeon-Pyo
中科院分区：
文献类型：
--
作者：
Choe, Yu-Ri;Jeong, Ju-Ri;Kim, Yeon-Pyo
背景：尽管骨质疏松症和虚弱是老年病中的重要疾病，但很少有研究调查这两种疾病之间的关系。因此，这项研究的目的是研究骨质疏松症的两个组成部分(肌肉质量和肌肉功能)与虚弱之间的关系。方法共有997名韩国老年人(456名男性和541名女性)参加了这项横断面观察性研究。我们使用多项式线性回归分析来获得标准化的性别、年龄和身高调整的附件骨骼肌块(ZASM)，以及标准化的性别、年龄和身高调整的握力(ZGS)。然后，我们进行了因果中介分析，以确认zASM和脆弱性之间的关系。结果在男性和女性中，ZGS均中介ZASM与脆弱之间的关系(男性的平均因果中介效应为-0.096{-0.159~-0.050}；女性的平均因果中介效应为-0.053{-0.098~-0.010})。ZGS得分每增加1分，男性脆弱程度增加1分的相对风险降低21%(e(-0.238)=0.788)，女性减少11%(e(-0.113)=0.893)。结论：在这项针对韩国老年人的研究中，肌肉质量并不直接影响脆弱程度，但通过改变肌肉功能产生间接影响。
Background Although sarcopenia and frailty are important diseases in geriatrics, few studies have investigated the association between the two diseases. Thus, this study aimed to examine the relationship between two components of sarcopenia (muscle mass and muscle function) and frailty. Methods In total, 997 Korean older adults (456 men and 541 women) were included in this cross-sectional observational study. We used a polynomial linear regression analysis to obtain standardized sex, age, and height-adjusted appendicular skeletal muscle mass (zASM), as well as to standardized sex, age, and height-adjusted grip strength (zGS). We then performed a causal mediation analysis to confirm the relationship between zASM and frailty. Results In both men and women, zGS mediated the relationship between zASM and frailty (average causal mediation effect in men: -0.096 {-0.159 to -0.050}; in women: -0.053 {-0.098 to -0.010}). For every one-point increase in zGS score, the relative risk of a one-point increase in frailty was reduced by 21% in men (e(-0.238) = 0.788) and by 11% in women (e(-0.113) = 0.893). Conclusions In this study on Korean older adults, muscle mass did not have a direct effect on frailty but had an indirect effect through altered muscle function.