Vasostatin, a calreticulin fragment, inhibits angiogenesis and suppresses tumor growth.
Vasostatin, a calreticulin fragment, inhibits angiogenesis and suppresses tumor growth.
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DOI：
10.1084/jem.188.12.2349
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发表时间：
1998-12-21
期刊：
影响因子：
--
通讯作者：
Tosato G
中科院分区：
文献类型：
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作者：
Pike SE;Yao L;Jones KD;Cherney B;Appella E;Sakaguchi K;Nakhasi H;Teruya-Feldstein J;Wirth P;Gupta G;Tosato G
从EB病毒永生化细胞系的上清液中纯化内皮细胞抑制剂，并鉴定为钙网蛋白片段。纯化的重组钙网蛋白的NH 2-末端结构域（氨基酸1-180）抑制内皮细胞的增殖，但不抑制其他谱系的细胞，并抑制体内血管生成。我们将其命名为钙网蛋白vasostatin的NH 2-末端结构域。当接种到无胸腺小鼠，vasostatin显着降低人伯基特淋巴瘤和人结肠癌的生长。与其他血管生成抑制剂相比，血管抑素是一种小分子、可溶性、稳定性好、易于生产和递送的分子。作为一种特异性靶向增殖内皮细胞的血管生成抑制剂，血管抑素在肿瘤治疗中具有独特的潜力。
An endothelial cell inhibitor was purified from supernatant of an Epstein-Barr virus–immortalized cell line and identified as fragments of calreticulin. The purified recombinant NH2-terminal domain of calreticulin (amino acids 1–180) inhibited the proliferation of endothelial cells, but not cells of other lineages, and suppressed angiogenesis in vivo. We have named this NH2-terminal domain of calreticulin vasostatin. When inoculated into athymic mice, vasostatin significantly reduced growth of human Burkitt lymphoma and human colon carcinoma. Compared with other inhibitors of angiogenesis, vasostatin is a small, soluble, and stable molecule that is easy to produce and deliver. As an angiogenesis inhibitor that specifically targets proliferating endothelial cells, vasostatin has a unique potential for cancer treatment.