Alcohol and HIV disease progression: weighing the evidence.
Alcohol and HIV disease progression: weighing the evidence.
复制标题
DOI：
10.1007/s11904-010-0060-6
复制
发表时间：
2010-11-01
影响因子：
4.6
通讯作者：
Samet, Jeffrey H
中科院分区：
文献类型：
--
作者：
Hahn, Judith A;Samet, Jeffrey H
大量饮酒在艾滋病毒感染者中很常见;然而，饮酒对艾滋病毒疾病进展的不利影响程度尚未完全阐明。相当强有力的证据表明，大量饮酒会导致行为和生物学过程，可能会增加艾滋病毒疾病的进展，而大量饮酒对猕猴中猿猴免疫缺陷病毒的生物学影响的实验证据也很有启发性。然而，20世纪90年代进行的几项关于大量饮酒对艾滋病进展影响的观察性研究发现，大量饮酒与艾滋病诊断时间无关，而最近的一些研究表明，大量饮酒与CD 4细胞计数下降和艾滋病病毒载量的非抑制有关。我们讨论了酒精可能导致HIV疾病进展的几种合理的生物学和行为机制，来自前瞻性观察性人类研究的证据，并建议未来的研究进一步阐明这一重要问题。
Heavy alcohol use is commonplace among HIV-infected individuals; however, the extent that alcohol use adversely impacts HIV disease progression has not been fully elucidated. Fairly strong evidence suggests that heavy alcohol consumption results in behavioral and biological processes that likely increase HIV disease progression, and experimental evidence of the biological effect of heavy alcohol on simian immunodeficiency virus in macaques is quite suggestive. However, several observational studies of the effect of heavy alcohol consumption on HIV progression conducted in the 1990s found no association of heavy alcohol consumption with time to AIDS diagnosis, while some more recent studies showed associations of heavy alcohol consumption with declines of CD4 cell counts and nonsuppression of HIV viral load. We discuss several plausible biological and behavioral mechanisms by which alcohol may cause HIV disease progression, evidence from prospective observational human studies, and suggest future research to further illuminate this important issue.