Functional coupling between anterior prefrontal cortex (BA10) and hand muscle contraction during intentional and imitative motor acts
Functional coupling between anterior prefrontal cortex (BA10) and hand muscle contraction during intentional and imitative motor acts
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DOI：
10.1016/j.neuroimage.2007.09.043
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发表时间：
2008-02-01
期刊：
影响因子：
5.7
通讯作者：
Rektor, Ivan
中科院分区：
文献类型：
--
作者：
Babiloni, Claudio;Vecchio, Fabrizio;Rektor, Ivan
本研究验证了功能性皮质-肌肉耦合是前额叶皮质Brodmann区10区(BA10)控制受试者行为的一种可能的生理机制的假说。术前监测癫痫患者的脑干听觉诱发电位(BA10)，记录SEEG数据。在SEEG记录期间，这些受试者在三种情况下进行：由听觉刺激触发的故意手部肌肉收缩(“EXE”)；模仿坐在受试者前面的人进行相同的肌肉收缩(“IMI”)；以及仅仅观察该人进行的手部肌肉收缩(“OBS”)。感兴趣的SEEG频段是θ(4-7赫兹)、阿尔法(8-12赫兹)、贝塔1(13-21赫兹)、贝塔2(2230赫兹)和伽马(31-45赫兹)。结果表明，在故意肌肉收缩(EXE)时，伽马频段的功能性皮质肌耦合(EXE)的幅度高于其他条件(IMI和OBS)。相反，在模拟肌肉收缩(“IMI”)时，theta带的皮质-肌肉耦合的幅度高于其他条件(“EXE”和“OBS”)。同时，肌肉有意收缩时SEEG伽玛频段功率增加，模仿时SEEG theta频段功率增加。本研究结果提示，前额叶皮质(BA10)可能通过选择性频段(theta和宽伽马节律)的功能性皮质-肌肉耦合来控制受试者的行为。(C)2007 Elsevier Inc.保留所有权利。
The present study tested the hypothesis that functional cortico-muscular coupling is a putative physiological mechanism by which Brodmann area 10 (BA10) of anterior prefrontal cortex controls subjects' behavior. Intracerebral stereo electroencephalographic (SEEG) data were recorded from BA10 of epilepsy subjects in the course of pre-surgical monitoring. During the SEEG recordings, these subjects were engaged in three conditions: the execution of intentional hand muscle contractions as triggered by auditory stimuli ("EXE"); the execution of the same muscle contractions as an imitation of a person seated in front of the subject ("IMI"); and the mere observation of the hand muscle contractions performed by that person ("OBS"). SEEG frequency bands of interest were theta (4-7 Hz), alpha (8-12 Hz), beta 1 (13-21 Hz), beta 2 (2230 Hz), and gamma (31-45 Hz). Results showed that functional corticomuscular coupling at gamma band was higher in amplitude during the intentional muscle contraction ("EXE") than the other conditions ("IMI" and "OBS"). Instead, cortico-muscular coupling at theta band was higher in amplitude during the imitative muscle contraction ("IMI") than the other conditions ("EXE" and "OBS"). In parallel, there was an increase of SEEG gamma band power during the intentional muscle contraction and an increase of SEEG theta band power during its imitation. The present results suggest that anterior prefrontal cortex (BA10) might control subjects' behavior by means of functional cortico-muscular coupling at selective frequency bands (theta and wide gamma rhythms). (c) 2007 Elsevier Inc. All rights reserved.