Noxious tooth pulp stimulation suppresses c-fos expression in the rat hippocampal formation
Noxious tooth pulp stimulation suppresses c-fos expression in the rat hippocampal formation
复制标题
DOI：
10.1016/s0006-8993(99)01250-0
复制
发表时间：
1999-05-08
期刊：
影响因子：
2.9
通讯作者：
Matsuo, R
中科院分区：
文献类型：
--
作者：
Funahashi, M;He, YF;Matsuo, R
采用免疫组化方法，观察了机械伤害性刺激大鼠下颌切牙髓后海马（阿蒙角和齿状回）及后海马（下托、前下托、下托旁和内嗅皮质）即刻早期基因c-fas表达的变化。下托、CAI、齿状回和深内侧内嗅皮质中的对照水平最高。其他地区的水平较低，但也很高。而弱刺激牙本质引起的c-fos的表达增加，在某些地区，这是没有统计学意义，强牙髓刺激引起的c-fos的表达在每个区域，除了对侧下托双边下降。双侧丘脑底核旁浅层（p < 0.01）、双侧海马CA 1区及同侧内侧内嗅皮质浅层（p < 0.05）均明显降低。我们认为，海马结构区域的抑制电路可能被激活外周有害的体感输入，这种变化的活动是伴随着立即早期基因，c-fos的表达的变化。(C)1999 Elsevier Science B. V.保留所有权利。
Changes in the expression of immediate early gene c-fas by noxious mechanical stimulation to the mandibular incisor pulp of rats were immunohistochemically examined in the hippocampus (Ammon's horn and dentate gyrus) and the retrohippocampus (subiculum, presubiculum, parasubiculum and entorhinal cortex). The highest control levels were found in subiculum, CAI, dentate and deep medial entorhinal cortex. Lower, but substantial levels were present in the other areas. Whereas weak dentinal stimulation caused increases in c-fos expression in some regions which were not statistically significant, strong tooth pulp stimulation caused a bilateral decrease in c-fos expression in every region except contralateral subiculum. These decreases reached statistical significance in superficial layer parasubiculum bilaterally (p < 0.01), bilateral CA1 and ipsilateral side of superficial layer of medial entorhinal cortex (p < 0.05). We suggest that inhibitory circuitry in hippocampal formation regions may be activated by peripheral noxious somatosensory inputs and this change in activity is accompanied by a change in the expression of the immediate early gene, c-fos. (C) 1999 Elsevier Science B.V. All rights reserved.