The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection.
The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection.
复制标题
DOI：
10.3390/diseases6040095
复制
发表时间：
2018-10-20
期刊：
影响因子：
--
通讯作者：
Bethony, Jeff M
中科院分区：
文献类型：
--
作者：
Chang, Aileen Y;Tritsch, Sarah;Bethony, Jeff M
急性基孔肯雅感染期间细胞因子谱预测未来慢性关节炎尚未调查。我们进行了一项巢式病例对照研究，比较了急性基孔肯雅感染期间血清细胞因子浓度，报告存在慢性关节疼痛的病例（n = 121）与年龄和性别匹配的对照组（n = 121），后者报告感染后20个月恢复。我们观察到，在急性感染期间，强有力的细胞因子应答与慢性关节疼痛的发生率降低相关，并且在急性感染期间，低TNF α、IL-13、IL-2和IL-4可预测慢性关节疼痛。这些数据表明，一个强大的细胞因子反应是必要的病毒清除和细胞因子，在急性感染期间的免疫耐受可能是保护慢性关节炎的发病机制。
The cytokine profile during acute chikungunya infection that predicts future chronic arthritis has not yet been investigated. We conducted a nested case-control study comparing serum cytokine concentrations during acute chikungunya infection in cases (n = 121) that reported the presence of chronic joint pain versus age- and gender-matched controls (n = 121) who reported recovery at 20 months post infection. We observed that a robust cytokine response during acute infection was correlated with a decreased incidence of chronic joint pain and that low TNFalpha, IL-13, IL-2, and IL-4 during acute infection was predictive of chronic joint pain. These data suggest that a robust cytokine response is necessary for viral clearance and cytokines that are related to immune tolerance during acute infection may be protective for chronic arthritis pathogenesis.