The cytoplasmic domain of neuropilin-1 regulates focal adhesion turnover.
The cytoplasmic domain of neuropilin-1 regulates focal adhesion turnover.
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DOI：
10.1016/j.febslet.2013.08.040
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发表时间：
2013-11-01
期刊：
影响因子：
3.5
通讯作者：
Horowitz A
中科院分区：
文献类型：
--
作者：
Seerapu HR;Borthakur S;Kong N;Agrawal S;Drazba J;Vasanji A;Fantin A;Ruhrberg C;Buck M;Horowitz A
Though the vascular endothelial growth factor coreceptor neuropilin-1 (Nrp1) plays a critical role in vascular development, its precise function is not fully understood. We identified a group of novel binding partners of the cytoplasmic domain of Nrp1 that includes the focal adhesion protein FlnA. Endothelial cells (ECs) expressing a Nrp1 mutant devoid of a cytoplasmic domain (nrp1cytoΔ/Δ) instead of wild type Nrp1 migrated significantly slower in response to VEGF relative to nrp1+/+ cells. The rate of FA turnover in VEGF-treated nrp1cytoΔ/Δ ECs was an order of magnitude lower in comparison to nrp1+/+ ECs, thus accounting for the slower migration rate of the nrp1cytoΔ/Δ ECs.
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影响因子：
20.1
作者：
Salikhova A;Wang L;Lanahan AA;Liu M;Simons M;Leenders WP;Mukhopadhyay D;Horowitz A
通讯作者：
Horowitz A
DOI：
10.1042/bj20100580
发表时间：
2011-05-01
期刊：
The Biochemical journal
影响因子：
--
作者：
Pellet-Many C;Frankel P;Evans IM;Herzog B;Jünemann-Ramírez M;Zachary IC
通讯作者：
Zachary IC
影响因子：
4
作者：
Goel, Hira Lal;Pursell, Bryan;Mercurio, Arthur M.
通讯作者：
Mercurio, Arthur M.
影响因子：
4.8
作者：
Avraham, HK;Lee, TH;Avraham, S
通讯作者：
Avraham, S
影响因子：
4.8
作者：
Pan, Qi;Chathery, Yvan;Watts, Ryan J.
通讯作者：
Watts, Ryan J.