Estimation of age- and sex-specific background human serum concentrations of PCDDs, PCDFs, and PCBs in the UMDES and NHANES populations
Estimation of age- and sex-specific background human serum concentrations of PCDDs, PCDFs, and PCBs in the UMDES and NHANES populations
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DOI：
10.1016/j.chemosphere.2013.01.078
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发表时间：
2013-05-01
期刊：
影响因子：
8.8
通讯作者：
Garabrant, David H.
中科院分区：
文献类型：
--
作者：
Chen, Qixuan;Jiang, Xiaohui;Garabrant, David H.
年龄和性别对血清二恶英浓度的估计对于人群间的比较很重要。然而，这种比较是有问题的，因为人口的年龄和性别结构不同，价值观通常只在广泛的年龄范围内报告，而不同研究之间不具有可比性。很少有研究报道同种人特定的血清浓度，也没有研究提供按性别和年龄作为连续功能的浓度。我们将NHANES 2003-2004年的数据与密歇根大学二恶英暴露研究(UMDES)参考人群2005年的数据结合在一起，实现了对18-85岁以上性别的血清二恶英平均值和分位数的稳定和准确的估计。调查加权的线性和分位数回归模型以对数转换的同种物质浓度为结果，年龄、性别和数据来源为协变量的组合数据进行拟合。提供的公式允许计算年龄和性别特定的18-85岁以上的平均值和分位数估计。例如，根据公式可以估计50岁男性血清TEQ的几何平均值、中位数、第75个百分位数和第95个百分位数，密歇根州普通人群的脂类为18.33、19.02、22.60和30.37 pg g(-1)，美国非西班牙裔白人的脂类为15.71、15.89、22.60和29.90 pg(-1)。这些方法和结果有助于将任何个体的同种人血清二恶英浓度与一般人群的平均值、中位数、第75个百分位数和第95个百分位数进行比较，并将任何感兴趣的人群的血清二恶英浓度与美国和密歇根州的一般人群进行比较。(C)爱思唯尔有限公司出版的2013年。
Age- and sex-specific estimates of serum dioxin concentrations are important for comparisons among populations. However, such comparisons are problematic because populations have different age and sex structures and values are typically reported only in broad age ranges that are not comparable across studies. There are few studies that report congener-specific serum concentrations, and none that provide these by sex for age as a continuous function. We combined the NHANES 2003-2004 data with the University of Michigan Dioxin Exposure Study (UMDES) referent population 2005 data to achieve stable and accurate estimates of mean and quantiles of serum dioxins by sex over ages 18-85. Survey-weighted linear and quantile regression models were fitted on the combined data with the log-transformed congener concentration as outcome and age, sex, and data source as covariates. Formulas are provided to allow calculations of age- and sex-specific mean and quantile estimates over ages 18-85. For instance, the geometric mean, median, 75th percentile, and 95th percentile of serum TEQ for men aged 50 can be estimated, respectively, from the formulas as 18.33, 19.02, 22.60, and 30.37 pg g(-1) lipids among the Michigan general population, and as 15.71, 15.89, 22.60, and 29.90 pg g(-1) lipids among US non-Hispanic whites. These methods and results are useful for comparing the congener-specific human serum dioxin concentrations in any individual to the general population mean, median, 75th percentile, and 95th percentile, and for comparing the serum dioxin concentration in any group of interest to the US and the Michigan general populations. (C) 2013 Published by Elsevier Ltd.