Association between C-reactive protein and gestational diabetes: a prospective study
Association between C-reactive protein and gestational diabetes: a prospective study
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DOI：
10.1080/01443615.2019.1631767
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发表时间：
2019-08-27
影响因子：
1.3
通讯作者：
Mirabi, Parvaneh
中科院分区：
文献类型：
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作者：
Alamolhoda, Seideh Hanieh;Yazdkhasti, Mansoreh;Mirabi, Parvaneh
关于炎症因子对妊娠期糖尿病（GDM）影响的研究非常少。本研究的目的是探讨c反应蛋白（CRP）与GDM风险之间的关系。符合纳入标准且胎龄小于10周的孕妇被招募到本队列研究中，随访至妊娠24-28周。在第一次产前护理时采集所有孕妇的血液样本，调查血清CRP浓度和空腹血糖。妊娠24-28周，常规进行口服葡萄糖耐量试验诊断GDM。参与研究的女性中约有5%被诊断患有GDM。妊娠早期血清CRP浓度升高与GDM风险之间存在显著关联。血清CRP浓度最高的女性发生GDM的风险是血清CRP浓度最低的女性的3倍。全身性炎症可能与妊娠糖尿病风险增加有关。关于这个主题我们已经知道什么？多项研究表明，慢性炎症会增加患2型糖尿病的风险。对于筛查和诊断GDM的最佳态度存在不确定性。研究表明，炎性因子对GDM的影响非常有限。这项研究的结果补充了什么？在妊娠早期测量CRP水平可以被认为是一种筛查试验。在妊娠24-28周进行口服葡萄糖耐量试验时，这是一种简单且经济有效的方法。？ 这项研究的结果可以给医生和其他卫生保健提供者提示，妊娠早期血清CRP水平升高可能是妊娠糖尿病的一个危险因素。
Studies that examined the impacts of inflammatory factors on gestational diabetes mellitus (GDM) are very sparse. The purpose of this study was to investigate the relationship between C-reactive protein (CRP) and the risk of GDM. Pregnant women who fulfilled the inclusion criteria and their gestational ages were below 10 weeks were recruited to this cohort study and were followed up until the 24-28 weeks of gestation. At the first pre-natal care visit blood samples were taken from all the pregnant women to investigate the serum concentration of CRP and fasting blood sugar. At 24-28 weeks of gestation, an oral glucose tolerance test was done to diagnose GDM as routine. About 5% of the women participating in the study were diagnosed as having GDM. There was a significant association between the increased serum concentration of CRP in the first trimester and the risk of GDM. The risk of GDM in women with the highest serum concentration of CRP is three times higher than that of women with the lowest serum concentration of CRP. Systemic inflammation can be associated with increased risk of gestational diabetes.Impact statement What is already known on this subject? Multiple studies have shown that chronic inflammation can increase the risk of developing type2 diabetes. There is incertitude as to the best attitude for screening and diagnosis of GDM. The studies were examined the impacts of inflammatory factors on GDM is very restricted. What do the results of this study add? CRP level measurement in the first trimester can be considered as a screening test. This is an easy and cost-effective test to make decision for performing oral glucose tolerance test at 24-28 weeks of pregnancy. ? The results of this study could give physicians and other health care providers the hint that increasing serum CRP levels in early pregnancy can be a risk factor for gestational diabetes.