Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus
Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus
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DOI：
10.1210/jc.2005-1475
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发表时间：
2006-01-01
影响因子：
5.8
通讯作者：
Lee, YJ
中科院分区：
文献类型：
--
作者：
Chen, MP;Chung, FM;Lee, YJ
背景：内脏脂肪素（也称为前 B 细胞集落增强因子或 PBEF）是一种在内脏脂肪中高表达的细胞因子，其血液水平与肥胖相关。最初被分离为促进 B 细胞前体生长的分泌因子，最近发现其可作为胰岛素受体上的胰岛素类似物，其在人类中的病理生理学作用仍然很大程度上未知。 目的：在这项研究中，我们研究了 2 型糖尿病 (T2DM) 患者血浆内脂素水平是否发生改变。 设计和患者：血浆内脂素以及 通过 ELISA 测量 2 型糖尿病和非糖尿病受试者的脂联素和抵抗素浓度。结果：总共研究了 61 名 T2DM 患者和 59 名性别和年龄匹配的非糖尿病受试者。发现 T2DM 患者血浆内脂素升高（31.9 +/- 31.7 vs. 15.8 +/- 16.7 ng/ml，P = 0.002）。相反，脂联素降低（4.3 +/- 2.5 vs. 30.8 +/- 10.3 μg/ml，P < 0.001），而血浆抵抗素水平在各组之间没有差异。内脂素浓度的增加与 T2DM 独立且显着相关。多元逻辑回归分析显示，即使在对已知生物标志物进行全面调整后，内脂素仍是 T2DM 的独立关联因素。调整体重指数或腰臀比后，脂联素与 T2DM 之间的关联不再显着。在多元线性回归分析中，只有腰臀比与血浆visfatin水平独立相关。结论：我们的结果表明visfatin可能在T2DM的发病机制中发挥作用。
Context: Visfatin (also known as pre-B cell colony-enhancing factor or PBEF) is a cytokine that is highly expressed in visceral fat and whose blood levels correlate with obesity. Originally isolated as a secreted factor that promotes the growth of B cell precursors and recently found to act as an insulin analog on the insulin receptor, its pathophysiological role in humans remains largely unknown.Objectives: In this study we investigated whether plasma visfatin level is altered in patients with type 2 diabetes mellitus (T2DM).Design and Patients: Plasma visfatin as well as adiponectin and resistin concentrations were measured through ELISA in type 2 diabetic and nondiabetic subjects.Results: A total of 61 patients with T2DM and 59 sex- and age-matched nondiabetic subjects were studied. Plasma visfatin was found to be elevated in patients with T2DM (31.9 +/- 31.7 vs. 15.8 +/- 16.7 ng/ml, P = 0.002). In contrast, adiponectin was decreased (4.3 +/- 2.5 vs. 30.8 +/- 10.3 mu g/ml, P < 0.001), whereas plasma resistin level did not differ between the groups. Increasing concentrations of visfatin were independently and significantly associated with T2DM. Multiple logistic regression analysis revealed visfatin as an independent association factor for T2DM, even after full adjustment of known biomarkers. The association between adiponectin and T2DM was no longer significant after adjustments for body mass index or waist to hip ratio. In a multiple linear regression analysis, only waist to hip ratio was independently associated with plasma visfatin level.Conclusion: Our results indicate that visfatin may play a role in the pathogenesis of T2DM.