Nanoparticles: A Challenging Vehicle for Neural Stimulation.
Nanoparticles: A Challenging Vehicle for Neural Stimulation.
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DOI：
10.3389/fnins.2016.00105
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发表时间：
2016
影响因子：
4.3
通讯作者：
Benfenati F
中科院分区：
文献类型：
--
作者：
Colombo E;Feyen P;Antognazza MR;Lanzani G;Benfenati F
神经刺激是治疗影响中枢神经系统的几种疾病的强大且成熟的工具。尽管有效地减少了脑部疾病的症状或进展，但大脑最深区域的可及性差目前阻碍了更特异和受控的治疗刺激的可能性，这取决于侵入性手术方法和长期稳定性以及生物相容性问题。过去几十年对纳米材料和纳米器件的大量研究有利于开发新工具，以解决现有神经刺激方法的局限性。这篇简短的综述集中在纳米颗粒对神经元网络电生理活动的调制以及纳米结构-神经元界面相关的转导机制。
Neurostimulation represents a powerful and well-established tool for the treatment of several diseases affecting the central nervous system. Although, effective in reducing the symptoms or the progression of brain disorders, the poor accessibility of the deepest areas of the brain currently hampers the possibility of a more specific and controlled therapeutic stimulation, depending on invasive surgical approaches and long-term stability, and biocompatibility issues. The massive research of the last decades on nanomaterials and nanoscale devices favored the development of new tools to address the limitations of the available neurostimulation approaches. This mini-review focuses on the employment of nanoparticles for the modulation of the electrophysiological activity of neuronal networks and the related transduction mechanisms underlying the nanostructure-neuron interfaces.