Influence of Dihydromyricetin on Lowering Blood Glucose Concentration and Reducing Early Kidney Damage in Imparied Glucose Tolerance Rats
Influence of Dihydromyricetin on Lowering Blood Glucose Concentration and Reducing Early Kidney Damage in Imparied Glucose Tolerance Rats
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DOI：
10.4028/www.scientific.net/amr.1004-1005.857
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发表时间：
2014-08
期刊：
影响因子：
--
通讯作者：
Y. Zhou;T. Mao
中科院分区：
文献类型：
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作者：
Y. Zhou;T. Mao
糖尿病肾病是糖尿病的常见并发症，与不可逆性肾损害和慢性肾功能衰竭有关。糖耐量减低(IGT)是糖尿病和糖尿病肾病发展的早期阶段。早期发现糖耐量减低并治疗其相关的早期肾损害可有效预防糖尿病肾病的发展。本文研究了二氢杨梅素(DHM)对糖耐量低减(IGT)大鼠降血糖和减轻早期肾损害的作用。用D-半乳糖灌胃2周建立大鼠IGT动物模型，8周后按两个剂量水平灌胃DHM。观察两组大鼠空腹血糖(FBG)、餐后2小时血糖(2hBG)、胰岛素、肾脏微量白蛋白(MAlb)、尿素氮(BUN)含量及乳酸脱氢酶(LDH)活性，并与对照组比较。实验结果表明，DHM能显著降低大鼠餐后2小时血糖和胰岛素水平，降低肾脏mAlb含量和LDH活性，但对BUN水平无明显影响。提示DHM能有效改善IGT大鼠的状态，对早期肾损害有保护作用。
Diabetic nephropathy (DN) is a common complication of diabetes and it is related to irreversible kidney damages and chronic renal failure. Impaired glucose tolerance (IGT) is an early stage in the development of diabetes and DN. Early detection of IGT and treatment of its associated early kidney damage can effectively prevent the development of DN. In this paper, the influence of dihydromyricetin (DHM) on lowering blood glucose concentration and reducing early kidney damage in IGT rats was studied. Animal model of IGT rats was built by two week intragastric injection of D-galactose and treated with eight weeks of intragastric injection of DHM at two dose levels. The concentrations of fasting blood glucose (FBG), two-hour postprandial blood glucose (2hBG), insulin levels, contents of microalbuminuia (mAlb) and blood urea nitrogen (BUN), and activities of lactate dehydrogenase (LDH) in kidney were analysed and compared with those in control groups. Experimental results indicated that DHM treatment can significantly lower the levels of two-hour postprandial blood glucose and insulin, decrease the content of mAlb and the activities of LDH in kidney, but does not influence the level of BUN. The study suggested that DHM can effectively improve the states of IGT rats and provide a protective effect against early kidney damage.