Core-shell biopolymer nanoparticle delivery systems: Synthesis and characterization of curcumin fortified zein-pectin nanoparticles
Core-shell biopolymer nanoparticle delivery systems: Synthesis and characterization of curcumin fortified zein-pectin nanoparticles
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DOI：
10.1016/j.foodchem.2015.03.009
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发表时间：
2015-09-01
期刊：
影响因子：
8.8
通讯作者：
McClements, David Julian
中科院分区：
文献类型：
--
作者：
Hu, Kun;Huang, Xiaoxia;McClements, David Julian
以疏水性蛋白质（玉米醇溶蛋白）为核，亲水性多糖（果胶）为壳，制备了生物聚合物核壳纳米粒子。通过使用静电沉积（pH 4）用阴离子果胶分子涂覆阳离子玉米醇溶蛋白纳米颗粒来制备颗粒。核-壳纳米颗粒以高负载效率（>86%）用姜黄素（疏水生物活性分子）强化。所得的纳米颗粒是球形的，相对较小（直径250 nm），并且具有窄的尺寸分布（多分散指数0.24）。通过差示扫描量热法（DSC）检测，包封的姜黄素为无定形（而不是结晶形式）。傅里叶变换红外光谱和拉曼光谱表明，包埋姜黄素与玉米醇溶蛋白主要通过疏水作用相互作用。将纳米颗粒转化为具有良好水分散性的粉末形式。这些核-壳生物聚合物纳米颗粒可用于将姜黄素掺入功能性食品和饮料，以及膳食补充剂和药物产品中。(C)2015爱思唯尔有限公司版权所有。
Biopolymer core-shell nanoparticles were fabricated using a hydrophobic protein (zein) as the core and a hydrophilic polysaccharide (pectin) as the shell. Particles were prepared by coating cationic zein nanoparticles with anionic pectin molecules using electrostatic deposition (pH 4). The core-shell nanopartides were fortified with curcumin (a hydrophobic bioactive molecule) at a high loading efficiency (>86%). The resulting nanoparticles were spherical, relatively small (diameter 250 nm), and had a narrow size distribution (polydispersity index 0.24). The encapsulated curcumin was in an amorphous (rather than crystalline form) as detected by differential scanning calorimetry (DSC). Fourier transform infrared (FTIR) and Raman spectra indicated that the encapsulated curcumin interacted with zein mainly through hydrophobic interactions. The nanoparticles were converted into a powdered form that had good water-dispersibility. These core-shell biopolymer nanoparticles could be useful for incorporating curcumin into functional foods and beverages, as well as dietary supplements and pharmaceutical products. (C) 2015 Elsevier Ltd. All rights reserved.