Divergent Neural Processes Specific to the Acute and Sustained Phases of Verum and Sham Acupuncture
Divergent Neural Processes Specific to the Acute and Sustained Phases of Verum and Sham Acupuncture
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Verum 和 SHAM 针灸的急性期和持续期特有的不同神经过程
DOI：
10.1002/jmri.22393
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发表时间：
2011-01-01
影响因子：
4.4
通讯作者：
Tian, Jie
中科院分区：
文献类型：
--
作者：
Liu, Jixin;Qin, Wei;Tian, Jie
目的：讨论哪个大脑区域可能发挥作用并在针刺的即时反应和延迟反应之间切换。材料和方法：采用非重复事件相关功能MRI（fMRI）设计，研究针刺ST 36穴（ACU）和非经络穴（SHAM）引起的针刺效应的空间和时间模式。采用标准的一般线性模型来检测针刺的即时神经反应。结果：针刺引起边缘/边缘核区的信号变化，针刺延迟效应的功能整合网络出现了明显的变化。新皮质区，脑干和小脑的即时效果都在ACU和SHAM。这些脑区中的一些在ACU中表现出较强的延迟效应的功能连接。关联分析表明，在ACU的整个过程中，神经元起着关键作用。结论：本研究的结果表明，延迟效应可能反映了一个更显着的特点，潜在的针刺。鉴于脑岛作为中继站在立即反应和延迟反应之间切换，这表明不同的功能连接模式可能介导ACU和SHAM的针灸相关效应。
Purpose: To discuss which brain region potentially functioned and switched between the immediate and delayed response of acupuncture.Materials and Methods: A nonrepeated event-related functional MRI (fMRI) design was used to investigate the spatial and temporal patterns of acupuncture effects induced by needling an acupoint ST36 (ACU) and a nonmeridian point (SHAM). The standard general linear model was used to detect the immediate neural responses of acupuncture. Graph theory analysis was used to characterize the functional integrated network of the acupuncture delayed effect.Results: Acupuncture induced significant signal changes In the limbic/paralimbic areas. neocortical regions, brain-stem, and cerebellum for immediate effect both in ACU and SHAM. Some of these brain regions showed strong functional connectivity for a delayed effect in ACU. Conjunction analysis showed that the insula played a critical role during the overall process of ACU. No overlapping brain regions were found in SHAM.Conclusion: The findings of this study suggested that the delayed effects may reflect a more significant characteristic underlying acupuncture. Given that the insula as a relay station switched between the immediate and delayed response, it suggested that divergent functional connectivity patterns may mediate the acupuncture-related effects for ACU and SHAM.