Leptin treatment ameliorates anxiety in ob/ob obese mice
Leptin treatment ameliorates anxiety in ob/ob obese mice
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DOI：
10.1016/s1056-8727(02)00185-x
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发表时间：
2003-03-01
影响因子：
3
通讯作者：
Kasuga, M
中科院分区：
文献类型：
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作者：
Asakawa, A;Inui, A;Kasuga, M
我们研究了给药瘦素是否会影响ob/ob小鼠的焦虑样行为。连续5天反复腹腔注射瘦素。焦虑以标准升高加迷宫的方式进行评估。每天测量体重。反复给药瘦素显著增加了张开双臂的总入口数和总入口数的百分比。治疗后体重显著降低13.2%。瘦素治疗不仅能改善肥胖，还能改善ob/ob小鼠的焦虑。我们的研究结果表明，肥胖的治疗可能导致心理问题的解决。(C) 2003爱思唯尔科学有限公司版权所有。
We investigated whether or not administered leptin influences anxiety-like behavior in ob/ob mice. Repeated intraperitoneal administrations of leptin were continued for 5 days. Anxiety was assessed in the standard elevated plus maze. Body weight was measured daily. Repeated administrations of leptin significantly increased the percentage of the total number of entries in the open arms and the number of total entries. The body weight was significantly reduced by 13.2% after treatment. Leptin treatment ameliorated not only obesity but also anxiety in ob/ob mice. Our results indicate that the treatment of obesity may lead to the solution of psychological problems. (C) 2003 Elsevier Science Inc. All rights reserved.