Elastic Fibre Proteins in Elastogenesis and Wound Healing.

Elastic Fibre Proteins in Elastogenesis and Wound Healing.
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DOI:
10.3390/ijms23084087
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发表时间:
2022-04-07
影响因子:
5.6
通讯作者:
--
中科院分区:
生物学2区
文献类型:
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作为我们结缔组织的重要组成部分,弹性纤维使主要血管,皮肤和肺部等组织具有弹性。它们的形成是复杂的,受多种因素的协调调节。在这篇综述中,我们描述了弹性蛋白的主要参与者:taglipin-1,原弹性蛋白,潜伏TGFβ结合蛋白-4,和fibulin-4和-5。我们总结了它们在弹性纤维发生中的作用,讨论了它们的突变对相关疾病的影响,并描述了它们在形成弹性纤维网络中的相互作用。此外,我们研究了它们在伤口修复中的作用,以更好地了解它们在组织再生中的潜在应用。
As essential components of our connective tissues, elastic fibres give tissues such as major blood vessels, skin and the lungs their elasticity. Their formation is complex and co-ordinately regulated by multiple factors. In this review, we describe key players in elastogenesis: fibrillin-1, tropoelastin, latent TGFβ binding protein-4, and fibulin-4 and -5. We summarise their roles in elastogenesis, discuss the effect of their mutations on relevant diseases, and describe their interactions involved in forming the elastic fibre network. Moreover, we look into their roles in wound repair for a better understanding of their potential application in tissue regeneration.
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