Identification of Potential Intrafollicular Factors Involved in Selection of Dominant Follicles in Heifers1
Identification of Potential Intrafollicular Factors Involved in Selection of Dominant Follicles in Heifers1
复制标题
鉴定参与小母牛优势卵泡选择的潜在卵泡内因素1
作者：
M. Mihm;E. J. Austin;T. Good;J. Ireland;P. G. Knight;J. Roche;J. Ireland
Abstract A surgical procedure to aspirate follicular fluid concurrently from individual follicles from the same heifer was validated and used to determine if intrafollicular amounts of estradiol, progesterone, inhibins, activin-A, follistatins, and insulin-like growth factor binding proteins (IGFBP) differed for the future dominant compared with subordinate follicles during selection of the first wave dominant follicle. Heifers were subjected to surgery and aspiration of follicular fluid from the two or three largest follicles on Day 3 of the estrous cycle (∼1.5 days after emergence). Ultrasound was used to determine the fate of each aspirated follicle after surgery. At aspiration, diameter of the future dominant and largest subordinate follicle was similar in heifers. However, estradiol was higher, whereas IGFBP-4 was lower in the future dominant compared with the largest or next largest subordinate follicles. Also, the future dominant follicle in most cohorts had the highest estradiol and lowest IGFBP-4 compared with future subordinate follicles. We concluded that: IGFBP-4 and estradiol may have key roles in determining the physiological fate of follicles during selection of the first wave dominant follicle in heifers, and that both are reliable markers to predict which follicle in a growing cohort of 5- to 8.5-mm follicles becomes dominant.
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影响因子：
4.8
作者：
G. Erickson;A. Nakatani;N. Ling;S. Shimasaki
通讯作者：
G. Erickson;A. Nakatani;N. Ling;S. Shimasaki
内源性胰岛素样生长因子-I 对于促卵泡激素刺激大鼠抑制素 α 亚基的表达是必需的。
影响因子：
3.6
作者：
Li,D;Kubo,T;Kim,H;Shimasaki,S;Erickson,GF
通讯作者：
Erickson,GF
牛卵泡抑制素九种不同的生物和免疫活性分子变体的分离。
影响因子：
3.6
作者：
Good,TE;Weber,PS;Ireland,JL;Pulaski,J;Padmanabhan,V;Schneyer,AL;Lambert-Messerlian,G;Ghosh,BR;Miller,WL;Groome,N
通讯作者：
Groome,N
影响因子：
--
作者：
Jian Zhou;T. Kumar;M. Matzuk;C. Bondy
通讯作者：
Jian Zhou;T. Kumar;M. Matzuk;C. Bondy
卵泡闭锁期间不同形式的抑制素含量的变化。
影响因子：
3.6
作者：
Ireland,JL;Good,TE;Knight,PG;Ireland,JJ
通讯作者：
Ireland,JJ