A functional connection between inferior frontal gyrus and orofacial motor cortex in human
A functional connection between inferior frontal gyrus and orofacial motor cortex in human
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DOI：
10.1152/jn.00609.2003
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发表时间：
2004-08-01
影响因子：
2.5
通讯作者：
Brugge, JF
中科院分区：
文献类型：
--
作者：
Greenlee, JDW;Oya, H;Brugge, JF
人类的额下回（IFG）在言语产生中起着重要的作用。IFG是一个高度卷曲和细胞结构多样的结构，典型地形成3个亚回。我们有理由推测，在说话过程中，IFG或其部分通过皮层联系影响初级运动皮层的口面表征区。为了验证这种皮质连接存在的假设，对14名接受手术治疗的难治性癫痫患者进行了术中电刺激束追踪实验。双极电刺激施加到IFG的网站，而由此产生的诱发电位记录从口面运动皮层，使用多通道记录阵列。刺激IFG在语言优势半球和非优势半球的运动皮层上诱发多相波形。诱发的波形具有一致的功能，跨学科。这些反应出现在中央前皮质的离散区域。刺激运动皮层也诱发IFG的部分反应。这些数据为人类IFG和orofacial运动皮层之间的功能联系提供了证据。
The inferior frontal gyrus ( IFG) of humans is known to play a critical role in speech production. The IFG is a highly convoluted and cytoarchitectonically diverse structure, classically forming 3 subgyri. It is reasonable to speculate that during speaking the IFG, or some portion of it, influences by corticocortical connections the orofacial representational area of primary motor cortex. To test the hypothesis that such corticocortical connections exist, electrical-stimulation tract tracing experiments were performed intraoperatively on 14 human subjects undergoing surgical treatment of medically intractable epilepsy. Bipolar electrical stimulation was applied to sites on the IFG, while the resulting evoked potentials were recorded from orofacial motor cortex, using a multichannel recording array. Stimulation of the IFG evoked polyphasic waveforms on motor cortex of both language-dominant and - nondominant hemispheres. The evoked waveforms had consistent features across subjects. The responses were seen in discrete regions on precentral cortex. Stimulation of motor cortex also evoked responses on portions of IFG. The data provide evidence for a functional connection between the human IFG and orofacial motor cortex.