CRITICAL ROLE OF THE PARAHIPPOCAMPAL REGION FOR PAIRED-ASSOCIATE LEARNING IN RATS
CRITICAL ROLE OF THE PARAHIPPOCAMPAL REGION FOR PAIRED-ASSOCIATE LEARNING IN RATS
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DOI：
10.1037/0735-7044.107.5.740
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发表时间：
1993-10-01
影响因子：
1.9
通讯作者：
EICHENBAUM, H
中科院分区：
文献类型：
--
作者：
BUNSEY, M;EICHENBAUM, H
人类健忘症患者在学习单词对之间的任意关联时受到严重损害。本报告探讨了海马系统的作用，在一个模拟的配对联想学习大鼠。受试者选择性损害海马旁区和控制进行了测试的气味指导配对关联任务。正常的老鼠很容易学会区分配对的同伴和各种错误配对的相同气味，而大多数海马旁损伤的动物却无法学习。然而，病变动物能够获得正确的反应，刺激对气味之间的关联是不需要的。这些发现扩展了嗅觉学习作为啮齿动物高阶学习能力研究模型的有用性，并表明在大鼠和人类中，海马区对于学习刺激之间的任意非空间关系至关重要。
Human amnesics are severely impaired in learning arbitrary associations between word pairs. This report examines the role of the hippocampal system in an analog of paired-associate learning developed for rats. Subjects with selective damage to the parahippocampal region and controls were tested on an odor-guided paired-associate task. Normal rats readily learned to distinguish paired associates from various mispairings of the same odors, whereas most animals with parahippocampal damage failed to learn. Lesioned animals were, however, able to acquire correct responses to stimulus pairs for which an association between odors was not required. These findings extend the usefulness of olfactory learning as a model for studies of higher order learning capacity in rodents and indicate that in rats, as in humans, hippocampal areas are critical for learning arbitrary nonspatial relationships between stimuli.