IMPACT OF PROPHYLACTIC PERCUTANEOUS ENDOSCOPIC GASTROSTOMY ON MALNUTRITION AND QUALITY OF LIFE IN PATIENTS WITH HEAD AND NECK CANCER-A RANDOMIZED STUDY
IMPACT OF PROPHYLACTIC PERCUTANEOUS ENDOSCOPIC GASTROSTOMY ON MALNUTRITION AND QUALITY OF LIFE IN PATIENTS WITH HEAD AND NECK CANCER-A RANDOMIZED STUDY
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DOI：
10.1002/hed.21700
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发表时间：
2012-01-01
影响因子：
2.9
通讯作者：
Hammerlid, Eva
中科院分区：
文献类型：
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作者：
Silander, Ewa;Nyman, Jan;Hammerlid, Eva
背景。这项随机研究的目的是检查预防性经皮内镜胃造口术 (PEG) 进行肠内营养是否可以预防营养不良、减少住院时间并改善健康相关的生活质量 (HRQOL)。方法。 134 名晚期头颈癌患者被随机分为预防性 PEG（研究组）或临床实践（对照组）。 2 年内 7 次记录患者的体重、体重指数 (BMI)、住院需要和 HRQOL。结果。住院时间没有发现差异。 6 个月后，研究组的 HRQOL 明显改善，体重减轻明显减少。在第一个研究年中，研究组中营养不良的患者人数持续减少了 10% 左右。研究组开始使用肠内喂养的时间明显更早，时间也明显更长 (p < .0001)。结论。预防性 PEG 与显着更早开始肠内营养、延长肠内营养使用时间、随着时间的推移营养不良患者的减少以及治疗开始后 6 个月时 HRQOL 的改善相关。 (C) 2011 年 Wiley 期刊公司 Head Neck 34：1-9，2012 年
Background. The purpose of this randomized study was to examine if a prophylactic percutaneous endoscopic gastrostomy (PEG) for enteral nutrition could prevent malnutrition, reduce hospital stay, and improve health-related quality of life (HRQOL).Methods. One hundred thirty-four patients with advanced head and neck cancer were randomized to either prophylactic PEG (study group) or clinical praxis (control group). Patients' weight, body mass index (BMI), need for hospitalization, and HRQOL were noted at 7 occasions during 2 years.Results. No difference in hospital stay was found. After 6 months, HRQOL was significantly better and the weight loss was significantly less in the study group. The number of malnourished patients were consistently about 10% lower in the study group during the first study year. The study group started to use enteral feeding significantly earlier and for a significantly longer time period (p < .0001).Conclusion. Prophylactic PEG was associated with significantly earlier start and longer use of enteral nutrition, fewer malnourished patients over time, and improved HRQOL at 6 months posttreatment start. (C) 2011 Wiley Periodicals, Inc. Head Neck 34: 1-9, 2012