Evaluation of injection augmentation treatment of hyaluronic acid based materials on rabbit vocal folds viscoelasticity
Evaluation of injection augmentation treatment of hyaluronic acid based materials on rabbit vocal folds viscoelasticity
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DOI：
10.1007/s10856-005-0531-2
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发表时间：
2005-06-01
影响因子：
3.7
通讯作者：
Ambrosio, L
中科院分区：
文献类型：
--
作者：
Borzacchiello, A;Mayol, L;Ambrosio, L
在注射透明质酸（透明质酸，HA）基材料后，在动物模型（兔）中研究了注射后六个月声带的粘弹性。结果表明，注射HA基材料的声带的粘弹性与用作对照的健康声带（未注射样品）相似。还进行了组织学分析，以研究植入6个月后注射材料的命运。基于HA的材料保持长达6个月，并且它们招募了诱导新结缔组织向内生长的成纤维细胞，从而导致内源性软组织增强。基于HA的化合物是进一步研究的良好候选物，目的是在声门功能不全中通过注射治疗恢复/保持声带的振动能力（C）2005 Springer Science + Business Media，Inc.
The viscoelastic properties of vocal folds after injection of hyaluronic acid (hyaluronan, HA) based materials have been studied in an animal model (rabbit) six months after injection. The results indicate that the viscoelastic properties of the vocal folds injected with the HA based materials are similar to the healthy vocal folds (non-injected samples) used as control. Histological analysis has been also performed to investigate on the fate of the injected materials after six months from the implant. The HA based materials remain up to six months and they recruited fibroblasts that induce the ingrowth of new connective tissue resulting in an endogenous soft tissue augmentation. The HA based compounds are good candidate for further studies aimed at restoring/preserving the vibratory capacity of the vocal folds with injection treatment in glottal insufficiency (C) 2005 Springer Science + Business Media, Inc.